Mo Lotfollahi
@mo_lotfollahi
ML for biology and drug discovery | Faculty @sangerinstitute @Cambridge_uni
Delighted to finally announce that Lotfollahi Lab starts this year at @sangerinstitute and @CC4AIM in Cambridge University. The lab will develop core AI/ml systems and also generate large scale multi-modal cellular data to advance cell engineering: sanger.ac.uk/group/lotfolla…
I will be at #ISMB/ECCB today at Liverpool giving a talk at Bioinformatics and AI track in UK today at 1640. (See elixiruknode.org/event/bioinfor… ) organized by Janet Thornton and Carole Goble. If you like to catch up and discuss science, DM me here
I fully agree, there are a lot of folks that reach out from CS with superb papers and want todo AIxBiology yet are not keen to understand biology and some consider data cleaning “donkey work”. The best methods out there are clearly designed based on inductive biases and elements…
For biological data, if you don't have deep expertise in this low value work called data cleaning, u r lacking a fundamental understanding of the idiosyncrasies of the data. Without this knowledge, it is impossible to seriously model data.
It was a fun conversation with Naked scientist podcast , thanks @NakedScientists for featuring our work at @sangerinstitute
25 years of the Human Genome Project. This episode features @richard_durbin @GeneticsCam @Cambridge_Uni on the history of genomics; @mehurles on the role of the @sangerinstitute; @ee_davenport on tackling sepsis; and @mo_lotfollahi on AI and the future. thenakedscientists.com/podcasts/naked…
Excellent example of the core issue I was trying to get at wrt "virtual cells" - optimizing a prediction objective will not necessarily provide an accurate representation of physical or biological phenomena. It's extremely important to be very clear about this. 1/
Can an AI model predict perfectly and still have a terrible world model? What would that even mean? Our new ICML paper formalizes these questions One result tells the story: A transformer trained on 10M solar systems nails planetary orbits. But it botches gravitational laws 🧵
Only two days left to apply! We're hiring ML scientists and postdocs interested in generative AI for DNA sequence modeling. 👉 Machine Learning for Sequence Modeling (Scientist/Engineer) – work with Jussi Taipale Apply here: sanger.wd103.myworkdayjobs.com/en-US/Wellcome…
Paper alert! Can we disentangle the effects of multiple covariates to predict multiple counterfactual outcomes at the single cell level? We introduce CellDISECT, the product of a fun collaboration with @ArianAmaani, @Antony_Rose_ , @teichlab, @Muzz_Haniffa, @mo_lotfollahi
(1/n) Can we disentangle the effects of multiple covariates (e.g., sex, age, disease) to predict multiple counterfactual outcomes at the single-cell level? We introduce CellDISECT, a causal generative model that addresses this by learning to generate synthetic counterfactuals…
My first ever paper is out as a preprint!✨ Proud to be a co–first author on CellDISECT, a causal model that disentangles covariates (age, organ, etc.) and learns unobserved effects at single-cell level🧬 We generate realistic counterfactuals by training with perturbations💥 👇
(1/n) Can we disentangle the effects of multiple covariates (e.g., sex, age, disease) to predict multiple counterfactual outcomes at the single-cell level? We introduce CellDISECT, a causal generative model that addresses this by learning to generate synthetic counterfactuals…
🚨 We're hiring! Apply for the Sanger Excellence Fellowship to join our lab at the intersection of AI & biomedical science at @sangerinstitute Open to early-career researchers from Black heritage backgrounds. 🔗 Apply: sanger.wd103.myworkdayjobs.com/en-US/Wellcome…
One more day to apply! Apply while you can:)
🚨 We’re hiring @sangerinstitute! Join us as a Postdoc or ML Scientist to build generative & foundation models for biology. 🧬 Spatial + single-cell omics 🧠 Diffusion, transformers, multimodal data 💊 Drug discovery via Open Targets Apply: Postdocs in computational biology…
Four more days to apply for postdoc and ML research scientist positions in my lab at @sangerinstitute at intersection of AIxBio
🚨 We’re hiring @sangerinstitute! Join us as a Postdoc or ML Scientist to build generative & foundation models for biology. 🧬 Spatial + single-cell omics 🧠 Diffusion, transformers, multimodal data 💊 Drug discovery via Open Targets Apply: Postdocs in computational biology…
It was a pleasure to have you 😊
I couldn't have hoped for a better conclusion to my visit to @sangerinstitute It was an incredible experience to be able to present my work from the last six months at the #AIxBio25 conference. I’d like to deeply thank @mo_lotfollahi and @gtesta72 for giving me this opportunity.
great lab with huge opportunities for cool science!
Five more days to apply! Reach out to me if you have any questions
Five more days to apply! Reach out to me if you have any questions
🚨 We’re hiring @sangerinstitute! Join us as a Postdoc or ML Scientist to build generative & foundation models for biology. 🧬 Spatial + single-cell omics 🧠 Diffusion, transformers, multimodal data 💊 Drug discovery via Open Targets Apply: Postdocs in computational biology…