Marco Buttigieg

I'm super excited to share that our work on clonal hematopoiesis in the tumour microenvironment is now published in @CellRepMed!! By tracking CH mutations from the blood into the tumour (CH-Tum), we uncovered some new insights about CH in solid cancer cell.com/cell-reports-m…

Scientists @CellPressNews reviewed 408 YouTube clips of sleeping cats and found 2/3 curled up on their left side. Here’s the neuroscience behind why:🧵 (Please watch their video abstract I put on the last post - it’s 100% worth it)

Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!

There are much more structural variants within our genomes than previously conceived, >26,000 per person nature.com/articles/s4158… nature.com/articles/s4158…

We're super excited to announce the 10 recipients of our @QueensuSCRI INAUGURAL 2025 Sinclair Graduate Scholars in Cancer Research awardees. Bravo and congratulations to Kaytlin, Marco, Simona, Samantha, Natasha, Monica, Fatin, Ashley, Laura & Julian!!!!

Delighted to share an updated review and our perspectives on clonal hematopoiesis and cancer in @NatureCancer in collaboration with Xiurong Cai and Bobby Bowman: rdcu.be/ewN62

We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)

I'm honoured to share that I've been selected as part of the final @CIHR_IRSC #VanierCanada CGS cohort! Very grateful for the support from my supervisors @QMyPath and Rob Vanner, as well as family, friends, and mentors from along the way! @QueensMDPhD @QueensuSCRI @QueensUHealth

Congrats & thanks to Katherine King & Katie Matatall @TheKingLab for inviting us to this collaboration @CellStemCell. Also to Alex McDonald, @marcobuttigieg_ , @DrFlashHeart & Susan Crocker @QueensUHealth @tmedQueens @QueensMDPhD . Our funding from #NFRF @SSHRC_CRSH, @CIHR_IRSC…

Collaborative work online now @CellStemCell provides insight into how mutant immune cells can help mitigate Alzheimer’s disease. Tet2-mutant myeloid cells are able to infiltrate the brain and clear β-amyloid, slowing cognitive decline. cell.com/cell-stem-cell…

Clonal hematopoiesis (CH, blood stem cells with mutations) is considered a risk factor for cardiovascular disease and other adverse health outcomes. But today we learn about its potential benefit vs Alzheimer's disease sciencedirect.com/science/articl…

🚨 New paper in @NatureGenet ! How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here! nature.com/articles/s4158…

Excited to announce our latest preprint is finally out! Huge collaborative work shared with @MurtazaNagree and supervised by @stephxie! 😍 Check it here! biorxiv.org/cgi/content/sh… @UofT @UHN @pmcancercentre

Such a well deserved standing ovation for Chris Booth and the Challenge trial. These data are quite powerful. Much stronger evidence than what we saw in plenaries today. #ASCO25

The most practice changing trial from #ASCO25 is now live on @NEJM .If this was a drug, this would be approved today. Globally relevant and low-cost intervention that is not only delaying relapse but actually improving survival. Perfect case example of a #cancergroundshot trial.…

What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72…

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica nature.com/articles/s4158…

Trio of studies, including this, ours & @rosslevinemd group. Tumor-infiltrating clonal hematopoiesis (TI-CH or CH-Tum) leads to: -worse cancer outcomes -inflammatory TME shaped by CH myeloid cells -potentially targetable changes sciencedirect.com/science/articl… biorxiv.org/content/10.110…