Matthew Miller

#1: CheC-PLS (pronounced ‘check, please’) is a new genomic technique. It relates to ChIP, but adds 4 crucial features: 1. contiguity (how distant events are regulated) 2. history (where a protein has been) 3. heterogeneity (single cell data) 4. context (mapping repeats).

Stewart, @m_p_miller et al. @UofUBiochem show that Stu2 displays dynamic localization patterns in the #CellCycle, with different kinetochore and microtubule distributions during distinct phases. hubs.la/Q03v39cM0

Trump blocks NIH review. I’m on a study section to review cancer grants but received this email today: NIH has paused all communication, as directed by the new administration (e.g. cnn.com/2025/01/21/hea… ), and that apparently includes a pause for all study section meetings

A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores biorxiv.org/content/10.110…

Second half of my PhD work is up on Biorxiv and I’m really happy how this story turned out. A kinase and phosphatase battle to phosphorylate Stu2 which gave us insights into how cells regulate anaphase onset. @m_p_miller @biorxivpreprint biorxiv.org/content/10.110…

Excited to share our new preprint on the #Hedgehog pathway! We uncover how #Smoothened (SMO), a noncanonical #GPCR, binds & inhibits #PKA via an intrinsically disordered region, mimicking known GPCR/PKA signaling complexes despite minimal sequence similarity. #AlphaFold #IDR

Thrilled to share our new paper in @ScienceMagazine, in which we identify p62/SQSTM1 as a critical regulator of micronuclei 🧬🔬🧫 #ScienceResearch science.org/doi/10.1126/sc…

Big thanks to all @DKW_2024 participants for excellent science, engaging conversations, and mountain excursions! We hope to see everyone in Oxford in 2027. Thanks also to our generous sponsors @EMBOevents @Co_Biologists @eLife @Chromosoma_EB @snsf_ch @UNIGEnews @EMBO

Check out my dispatch, highlighting three great articles on how Mps1 and Dam1 have a shared binding site at the budding yeast kinetochore. Articles from Westermann/ @AndreaMusacchi1, Miller, and Harrison groups. authors.elsevier.com/a/1jCED3QW8S6E…

One week left to register for the EMBO Dynamic Kinetochore Workshop in Caux, Switzerland. Great lineup of speakers and great location! Don't miss it! meetings.embo.org/event/24-kinet…

We are very grateful to @Co_Biologists and @EMBOevents for their generous support of the Dynamic Kinetochore Workshop 2024! Still a month left to register - please join us to hear all the recent kinetochore-related research and present your work meetings.embo.org/event/24-kinet…

We are excited to share our latest preprint on BioRxiv (doi.org/10.1101/2023.1…). Together with @AndreaMusacchi1 we investigated the regulated recruitment of Mps1 to the budding yeast kinetochore and propose a model that puts Mps1 localization under indirect regulation of Ipl1.

Excited to share our latest preprint, excellent work by Emily and @erinejenson! Extensive mutagenesis of the Ndc80c revealed a very busy 'interaction hub,' vital for Mps1 binding and competitive regulation of localization: biorxiv.org/content/10.110…

We are happy to present the official website of the DKW 2024 meeting - please spread the word and submit your abstracts! We have 20 slots for selected talks (prioritized for early career researchers). We hope to see many of you in Caux next year meetings.embo.org/event/24-kinet…

Kinetochore community save the date! The 8th EMBO Dynamic Kinetochore Workshop will happen from 17–20 June 2024 at Caux in Switzerland. Sign up for notifications at coming-soon.embo.org/w24-37 - the full website will be launched in September. #EMBOkinetochore2024 #DKW2024

I am incredibly honored to join the Pew Scholars family! Thank you @pewtrusts and @pewhealth for your support and for believing in our vision, and a huge thank you to both my mentors, past and present, and to all of my trainees and mentees.

Lack of Paxillin phosphorylation promotes single-cell migration in vivo, say Qian Xue @Qian7272, Minna Roh-Johnson @roh_johnson_lab and colleagues @UUtah: bit.ly/3WTxG2D @JamesCellBio #Development #Adhesion

The PathMaker Scholars application is live! PathMaker at the @huntsmancancer seeks to increase the participation of underrepresented students in biomedical cancer research and to encourage them to prepare for careers in research, medicine, and education. Apply Today!

We are hiring for two open rank positions! jobs.sciencecareers.org/job/620578/fac… jobs.sciencecareers.org/job/620575/fac… PNRI is a small, non-profit research institute in Seattle with a tight-knit faculty broadly interested in using genetics and genomics to understand human health and disease.

We have a new preprint up! A widespread methylotroph acyl-homoserine lactone synthase produces an atypical quorum sensing signal. biorxiv.org/content/10.110…