Sarah Lutz

What causes #brainfog in #COVID_19? Our new study @Brain1878 shows that mild SARS-CoV-2 infection suppresses #cerebrovascular Wnt/beta-catenin activity, opening the #blood_brain_barrier. BBB-targeted Wnt ligands mitigate cognitive impairment in mice. A brief tweetorial!

Thanks for the recognition, @vascularbiology ! I’m so proud of our team for this work ❤️

Blood borne #cytokines like #IL-10 are often elevated in chronic conditions associated with cognitive impairment (eg. #longCOVID). Protective or pathogenic? Here’s ⁦@sharmasorabh88⁩ unexpected findings in a mouse model of #diabetes. biorxiv.org/content/10.110…

Brain endothelial GSDMD activation mediates inflammatory blood-brain barrier breakdown nature.com/articles/s4158…. @Nature

The beautiful work of @Rishi_CUIMC was published in @NeuroCellPress today. Here we show that glutamatergic neuronal activity drives retinal deep plexus angiogenesis and blood-retina barrier maturation. cell.com/neuron/abstrac…

A significantly increased long-term risk of psychiatric disorders and psychotropic meds among people with Covid, and breakthrough infections (vs controls), reduced with vaccination #LongCovid nature.com/articles/s4156…

"Brain fog" is a particularly confounding symptom for people recovering from COVID. Researchers at @uiccom have identified a mechanism that causes this neurological problem in mice. And they found a treatment that helped prevent these changes. today.uic.edu/covid-brain-fo…

While my lab is obsessed with claudin-5, claudin-25 also has a critical role in regulating white matter integrity in the brain. Another great collaboration with Arnold Munnich @InstitutImagine @tcddublin academic.oup.com/hmg/article/do…

Congratulations to my graduate student, Dr. Cori Fain! Cori’s thesis work on CD8 T cell engagement of MHC Class I molecules on brain vasculature being required for lethal BBB disruption in experimental cerebral malaria made the cover of the February issue of BRAIN @Cori_Fain