Lucas Camillo
@lucascamillomd
Head of ML @ShiftBioscience • Tech Fellow @FundacaoEstudar
Rare moments make you stop, stare, and imagine their future impact. I’m thrilled to share one of those moments from our work at @ShiftBioscience. Over the last few years, the data often felt unreal. Today we compare the single-gene SB000 (Shift Bioscience 000) with the…
🔥 Super cool research in longevity by Shift Bioscience! A new preprint ("A single factor for safer cellular rejuvenation") from Shift Bioscience reports a striking finding: a single gene, SB000, achieves robust cellular rejuvenation across two germ layers—fibroblasts and…
The dream of waking up in the near future and being substantially younger at a cellular level is something I have the rare privilege to pursue each day. However, keeping this dream alive is contingent on the following (1) making timely and meaningful technical progress towards…
The dream of waking up in the near future and being substantially younger at a cellular level is something I have the rare privilege to pursue each day. However, keeping this dream alive is contingent on the following (1) making timely and meaningful technical progress towards…
NEW: No technology currently exists to repair damaged brain tissue and fully restore lost function. FRONT aims to enable millions with what is considered permanent brain damage to regain lost functions, including motor control, vision, and speech. arpa-h.gov/news-and-event…
Do deep generative models in single-cell omics really work for perturbation prediction? Some benchmark studies say yes: 🔗 arxiv.org/pdf/2408.10609 🔗biorxiv.org/content/10.110… Others say no: 🔗 arxiv.org/abs/2410.13956 🔗 BMC Genomics: bmcgenomics.biomedcentral.com/articles/10.11… To move beyond this…
@ShiftBioscience proposes an improved ranking system for virtual cell models to accelerate gene target discovery and drive cell rejuvenation therapies. In our latest publication authored by Head of Machine Learning, @lucascamillomd , we show that by introducing new metrics and…
Are you trying to build a so-called AI virtual cell? 🔬 Yet ... the mean still outperforms your perturbation-response prediction model. 😮💨 Our paper— just accepted to the 𝗚𝗲𝗻𝗕𝗶𝗼 𝗪𝗼𝗿𝗸𝘀𝗵𝗼𝗽 @ 𝗜𝗖𝗠𝗟 —dives into 𝘸𝘩𝘺 the mean excels and what you can do about it.…
🧵1/ LBF7 Spain is happening and we're doing something kinda wild: -We’re gathering the smartest people who want to SOLVE AGING -going to a longevity resort in the Spanish mountains -to learn, discuss and ACTUALLY BUILD stuff for 7 days straight Here’s what we’re cooking 👇
Thankyou @peterottsjo and @DrPatrickLinden for hosting me on the LEVITY @reachlevity podcast to discuss our preprint 'A single factor for safer cellular rejuvenation' and beyond! youtube.com/watch?v=vdOVKZ…
@SheekeyScience breaks down the @ShiftBioscience preprint 'A single factor for safer cellular rejuvenation' highlighting both the progress and caveats. Thanks @EleanorSheekey for opening up the frontlines of cellular rejuvenation to a larger audience! youtube.com/watch?v=cH_Ige…
Wear this T shirt- it guarantees a romantic, intelligent date in less than 10 days!
Thanks Steve and built on the shoulders of the methylation clocks, your manuscript in T-shirt form for our celebration today!
Genuine epigenetic rejuvenation in primary cells has long been the holy grail. A groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated…
Congrats to the whole team at Shift Bioscience!🔥
Rare moments make you stop, stare, and imagine their future impact. I’m thrilled to share one of those moments from our work at @ShiftBioscience. Over the last few years, the data often felt unreal. Today we compare the single-gene SB000 (Shift Bioscience 000) with the…
I’m excited to be part of a #SynBioBeta2025 panel discussing breakthroughs in epigenetic reprogramming and how this could transform Longevity biotech. Let’s connect in San Jose — whether you're building the next big thing in Longevity biotech, investing in the future, or just…
🚨 Big news! As promised, we’ve open-sourced the CpGPT codebase — bringing this powerful DNA methylation foundation model to researchers and developers worldwide: github.com/lcamillo/CpGPT/ 🖥️ The release includes model architecture, fine-tuning scripts, pre-trained weights, and a…
Excited to share CpGPT, a new foundation model for DNA methylation, crafted to understand the 'language' of epigenetics! 🧬🤖 What’s CpGPT? CpGPT is a transformer model pre-trained on CpGCorpus, a huge dataset of public DNA methylation info. By integrating sequence, positional,…
🚀 Huge News! @culongevity is hosting @prof_horvath , creator of the 1st epigenetic ageing clock🧬⏳! 📅 April 2, 2025 | ⏰ 2 PM | 📍 Wolfson Lecture Theatre, Cambridge Dept. of Chemistry ✨ Supported by @BGI_Genomics | Free & open to all! Register using our posters QR code 📲
Join the world's biggest longevity event! Vitalist Bay: Berkeley Apr 4-May 29 +45 new speakers, health-stack launch! 🚨Only today 5 of 1st 300 RTs get $10K health stack @ Vitalist Bay All-access pass, full genome, cell banking, VO2max,DEXA. Tests: blood, microplastics & more
Nature Review: Unlocking computational frontiers in epigenetic clocks. How will next-gen of epigenetic clocks unlock breakthroughs in cell rejuvenation? How will single-cell DNAm data reveal deeper insights? Andrew E. Teschendorff (2025) Epigenetic ageing clocks: statistical…
Excited to present our newest paper (doi.org/10.1101/2024.1…)! We employ single-cell RNA seq to characterise samples from live intracerebral haematomas with paired peripheral blood samples as controls and identify changes in myeloid cell dynamics over time, across tissues.