Simon Little
@littleneuro
Neurologist & Neuroscientist interested in Adaptive Brain Stimulation, Movement, Mood, Motivation, Sleep, Self Regulation, Psychology and Dadding!
1 million Americans have Parkinson’s disease. UCSF researchers are developing a new treatment, adaptive deep brain stimulation, that tunes into a patient’s brain signals and adjusts therapy as PD symptoms rise and fall. tiny.ucsf.edu/UFW7rX @littleneuro @NeurosurgUCSF
Happy to be launching this special edition in NPJ Parkinson’s on everything sleep and PD related!
Super happy to share this paper with Lucia Ricciardi and Bart Swinnen and others looking anxiety in PD! Turns out that basal ganglia theta indexes trait anxiety in 3 independent cohorts. academic.oup.com/brain/advance-…
Incredible resource from the hugely talented Bonaiuto lab. Want to run super high resolution MEG with laminar level hypothesis testing without having to write 10,000 lines of code?! Here’s your toolkit
🚨New laminar MEG toolkit🚨I'm so happy to be at @biomag2024 to announce the release of laMEG, an easy-to-install implementation of the simulations and analyses from our laminar MEG papers github.com/danclab/laMEG AND if you wish you could use SPM from python, keep reading👇🧵
Why is DBS still a 'black box' to many folks with Parkinson's and beyond? Great pic from @theNAMedicine @theNASciences by Lauren Hammer who won 2023 DBS Rising Star Challenge. Free download of the proceedings. Exploring the Adoption of Implantable Brain Stimulation into Standard…
Happy to share this preprint completed with @TantanBrainMan and colleagues! Why try and smooth over and ignore movement in adaptive DBS when you can target it directly? All completed remotely in our patients home with a fully automated end-to-end programming pipeline…
Excited to share a preprint of work done together with folks from UCSF (@littleneuro), UC Berkeley, and U of Washington, using neural decoding and adaptive DBS to selectively amplify movement when intended and reduce dyskinesia when it isn't medrxiv.org/content/10.110…
So proud of our 3 female first co-authors who led this project @CarinaOehrn, @scernera1 & @LaurenHHammer along with friend and co-senior author Philip Starr. Adaptive DBS for Parkinson's is out of the lab and into the real-world!
The most creative, intense, and rewarding project I’ve ever worked on! Now out @NatureMedicine. Real-world blinded adaptive DBS halves time with motor symptoms and improves quality of life in Parkinson’s disease. With the amazing @scernera1 @LaurenHHammer @littleneuro Philip…
Our study on reward and effort signals in PFC theta and basal ganglia beta is now out in @PNASNews! Big thanks to the team (esp @coradehemptinne and @littleneuro), reviewers, and patients. pnas.org/doi/10.1073/pn… Data: osf.io/jq6z4/ Code: github.com/hoycw/PRJ_OFC_…
My 1st postdoc preprint! iEEG dissociates reward/effort in PFC theta/BG beta during decisions + PFC stim boosts reward effect on choice. Huge thanks: @coradehemptinne & @littleneuro for heavy lifting early on & Sarah Wang, @OxfordPERL, @brain_apps, @MasudHusain, Philip Starr!🧵⤵️
Video-based machine learning can help clinicians predict motor impairment severity for patients w/ #ParkinsonsDisease, a study finds. The system "could support faster & better diagnostics & treatment in the future.” UCSF’s Dr. Simon Little says. ucsfh.org/45ZEoKO
There are 17 DBS and neuromodulation articles now published in Volume IV @DBSThinkTank @FrontNeurosci and the editorial is 'fresh' out this week and led by @karaannjohnson The DBS Think Tank Proceedings led @JWongggMD also out. Read about: 1- Improving clinical practice and…
Super happy to share some work by an awesome team led by @fahim_naruto investigating NREM sleep dysfunction in PD. Turns out that beta burst aren’t just naughty in the daytime… doi.org/10.1038/s41467…
🧠 Exciting News! Thrilled to announce the commencement of our new study exploring cerebellar deep brain stimulation to enhance mobility and quality of life in children/young adults with cerebral palsy. Details below👇 #CerebralPalsy #DBS clinicaltrials.ucsf.edu/trial/NCT06122…
Excited to share this paper using new neurotech and explainable AI to advance DBS for treatment resistant #depression (TRD). Team effort including @HelenMaybergMD, @sankar_alagapan and Patricio Riva-Posse. Summary thread! go.nature.com/48lmlzC @nature PC: Mike Halerz