Luciano A. Masullo
@l_masu
Physicist | single molecules, bioscience, biotech, nanotech, optics, fluorescence | Project Leader @JungmannLab @MPI_Biochem
ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out today in @Nature! nature.com/articles/s4158… @JungmannLab @MPI_Biochem
🚨 New paper alert! 🚨 Can we simultaneously achieve deep, high-res, large field-of-view imaging without the usual trade-offs? 🤔 🧬🔬 YES: #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC_OPR)! #SuperResolution 📄 nature.com/articles/s4146… @NatureComms 🧵👇
Ayuda con la difusión! Buscamos personas interesadas en hacer un doctorado CONICET en un proyecto interdisciplinario, desarollando microscopios ópticos para adquirir imágenes neuronales en animales vivos. Más info del proyecto en el flyer y el hilo abajo... @leloir
HIGH-RESOLUTION IN VIVO BRAIN IMAGING OF DROSOPHILA 🪰 New Preprint by Tassara et al.! biorxiv.org/content/10.110… #FluorescenceMonday #SnoutClub 1/6
I’m excited, relieved, and honored to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @ScienceMagazine ! (link at end of 🧵)
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution We are excited to present our latest work published in @NatureComms nature.com/articles/s4146…
Gran oportunidad para ayudar a reconstruir la Universidad Nacional del Sur, en Bahía Blanca, luego que las inundaciones hayan destruidos sus Labos. Ayudemos a nuestros colegas. Todo el apoyo de @Fisica_UBA !!
📚✨ RECONSTRUYAMOS LA UNIVERSIDAD NACIONAL DEL SUR Bahía y la UNS necesitan tu ayuda. Tras la inundación del 7 de marzo cada aporte es vital para reconstruir nuestra universidad. Doná y compartí!! reconstruir.uns.edu.ar
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬 For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime Preprint and tweetorial below!!
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy biorxiv.org/content/10.110…
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy biorxiv.org/content/10.110…
¡Concluyó el segundo día de #FOMISUR2024 después de una larga jornada de mediciones de STED, DNA-PAINT y análisis de datos! @FernaStefani @cibionconicet
#FOMISUR super-resolution microscopy workshop starts now! So happy to be here in my hometown Buenos Aires for this great event! Thanks to the organizers (@FerStefaniLab, @SzalaiAlan, @luhalac1, Javier Adur) for the invitation!
New protein labelling SUM-PAINT enables high throughput, high res, multiplex imaging 📷: @EduardUnterauer, Sayedali Shetab Boushehri & Kristina Jevdokimenko et al @euforna @uniGoettingen @JungmannLab @MPI_Biochem in @CellCellPress ➡️: bpod.org.uk/archive/2024/1… with @AntDLewis
I was lucky to share the lab with the brilliant @luciana_nano for a few years and see some of the backstage of these amazing projects! Wonderful work in nanophotonics! Congrats LPM! 🤩🥳🎓
Congratulations Dr. Luciana Martinez @luciana_nano Luciana made a wonderful experimental work on single-particle spectroscopy with applications in anti-Stokes nanothermometry and precise closed-loop control of photochemical reactions on nanoparticles. @IanVioli @FernaStefani
We are all super excited to have you onboard!! 🤩 Looking forward to working together! 🧬🎨🦠
What a great way to announce my new post doctoral research position with the @JungmannLab by showing off my amazing graduation hat made by my fellow lab members! Thank you all for my wonderful gifts.
We are live at the @LMU_Muenchen Physics Science Fair! Come to our poster to learn about what we do at the @JungmannLab! We have several research projects for students at Bachelor and Master level!
DNA/protein conformation dynamics with Ångström resolution in a fluorescence microscope 🤯
Can we study DNA and DNA/protein conformations with Ångström/sub-second resolution in a fluorescence microscope? With GETvNA, we sure can! Check out our new paper in @naturemethods: nature.com/articles/s4159… @LabTinnefeld Curious about how GETvNA works? 1/n🧵
Can we study DNA and DNA/protein conformations with Ångström/sub-second resolution in a fluorescence microscope? With GETvNA, we sure can! Check out our new paper in @naturemethods: nature.com/articles/s4159… @LabTinnefeld Curious about how GETvNA works? 1/n🧵
Light-mediated spatiotemporal control of local cell-death induction *without genetic editing*! 💡⚡️🧫💀 A great alternative to optogenetics using smartly engineered molecules! Super interesting work by the amazing @KarimAlmahayni, @LMoeckl, and team!
Excited to see this one out! tinyurl.com/jh57vvbn We develop and characterize a new light-based method to induce oxidative stress in biological systems, in vitro and in vivo. Spearheaded by @KarimAlmahayni and Jana Bachir in collab with @WehnerLab and the Grützmacher group!
Super cool work combining DNA nanotech, single molecule sensing and imaging! 🤩
Check out our most recent work on monitoring the protective coating of single DNA origami nanostructures with a molecular fluorescence lifetime sensor: biorxiv.org/content/10.110…
🚀Very excited to share our recent publication in which we present a novel PSF-fitting approach for localization microscopy of single molecules near spherical nanoparticles🥳 pubs.acs.org/doi/full/10.10… 🧵[1/4]
PSFs are just Gaussians, right?? Not when your fluorophore💡is close to a nanoparticle 🟠! Excited to share our preprint in which we present a novel PSF-fitting approach for localization microscopy near nanoparticles.🥳 doi.org/10.48550/arXiv… Main findings below: [1/9]
Thrilled to share our latest work in @NanoLetters! Can we measure association and dissociation constants within cell environments? Check out how we use single-molecule localization microscopy to determine protein-protein interactions in T cells. 🥼🔬 💪 doi.org/10.1021/acs.na…
Do you know what I love most about my PhD @JungmannLab? Actually seeing the things I learned from biology textbooks come to life🪄. Check out this DNA-PAINT image of the Golgi, showing both cis (GM130) and trans (TGN38) faces together with peroxisomes. Happy #FluorescenceFriday😊