Jonathan P. Karr

So this happened while I was vacationing. Jack and I at the @TjianDarzacq lab combined SM imaging with domain chopping (à la classical biochemistry) to determine which bits of p300 make it bind to chromatin in living cells. Turns out it's all about TF binding.

The “Suicide” of the Liberal Arts: Naomi Schaefer Riley interviews John Agresto wsj.com/articles/the-s…

Can scientists be taught how to choose good projects? I took a fantastic class taught by @mfgrp last quarter where the foundational hypothesis is: Yes, they can! And I continually come back to these core insights as I think about project choice and direction in my 2nd year of…

Excited to finally release the @biorxivpreprint of my first ever first author paper! 🚨🥳🥳🚨biorxiv.org/content/10.110… Any enhancer lovers in the feed!?! You know what time it is-- We're going deep! ./tweetorial.sh👇🧵

Elegant work on TF-cofactor and cofactor-promotor compatibility. This is exactly the sort of experiment needed to push our mechanistic understanding of transcription forward.

Local PhD says: Do this every day to detect protein-protein interactions using photoactivation. (Figure 6 will shock you!) 🍎🍐🥦🍊🥑 elifesciences.org/articles/76870 @tgwgraham, Jack Ferrie, Gina Dailey, @XDarzacq, @TjianDarzacq

If I were prone to confirmation bias, I might think these findings rather suggestive of a certain model.