John Novembre

Tried to squeeze this in last week, but, well... Now, proud to share a paper that came out over the holiday break. We explore a new approach to showing basic patterns of human allele frequency variation. doi.org/10.7554/eLife.…

The impact of background selection in mutation-selection-drift balance models of complex trait evolution biorxiv.org/content/10.110… #biorxiv_evobio

Excited to share our latest preprint on the impact of background selection on complex trait evolution. It’s amazing to finally see one of the major projects from my PhD journey come to life. Huge thanks to @JeremyJBerg and @jnovembre for their guidance and support.

Very excited about this new functionality added to our software for representing genetic structure in a geographic context, and very great working with @VivaswatShastry! Btw - He's graduating and looking for biotech/data science jobs in industry and would be a great hire

#ASHG24 - Check out our new methods to reveal population structure through time -- poster 3026F presented today by Ahmed Selim from the lab!

#ASHG24 make your way to today’s Novembre lab posters 3015 (label free reference matching, @LukeAnderTroc) 3016 (rare variant discovery, @maggiecsteiner ) and 4041 (impacts of multigeneration shared environments, @mkiravn) to see some great science!

I am looking for a postdoc to work in theoretical population genetics. We focus on theory and methods for inferring demographic histories and selection using modern and ancient genomic data. Come join our amazing community in Chicago. More info here: steinrueckenlab.uchicago.edu/files/2024/11/…

Wow - @PiusTonu just put together an amazing video for the qBio program we run for incoming PhD students here at UChicago. Such a pleasure to welcome another year of biology PhD students to Chicago and work with such talented TAs, co-instructors, and students. Thanks @PiusTonu!

Come join us! UChicago Human Genetics has an open broad computational faculty search (with an emphasis on probabilistic machine learning). First round of application review will begin ~October 15th. apply.interfolio.com/149891 EOE/Vet/Disability.

Just a few weeks left to apply to this Human Genetics position in Berkeley IB! Over the last 7 years IB has hired 12 assistant professors (!including me!) and is an incredibly supportive environment. I can't wait to welcome a new colleague! aprecruit.berkeley.edu/JPF04502

It’s time for the official announcement: the Luca Lab is moving to UChicago ⁦⁦⁦@HGEN_UChicago⁩ - get in touch if you are interested in studying GxE in the Windy City!

New preprint, with @SherifNegm3632 "The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection" doi.org/10.1101/2024.0… 1/

[Negm, Veller, doi.org/10.1101/2024.0…] derive a more accurate solution for the effect of stabilizing selection on allele frequency that accounts for background phenotypic variance and LD. If you (like me) are using the first one, you should start using the second one.

Super cool work from @jblanc12 & @jeremymberg using first principles to derive estimators of biases in PGS and PGS-based associations. biorxiv.org/content/10.110…

Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…

Looking forward to our symposium this Friday! An amazing lineup of speakers who are all alumni of our GGSB graduate program, plus a career-focused panel discussion, and a reception Friday, 9:30am, KCBD auditorium, UChicago All are welcome! Please RT & share!

New work from the lab! We present a novel method for inferring the geographic locations of shared genetic ancestors and use it to infer the geographic history of human genetic ancestry biorxiv.org/content/10.110…

Surfing trees!!! 🏄‍♀️🌊🌳 I really enjoyed writing this perspective with @dortega_delv @CharlestonCWKC @christiandhuber. We talk about the promises of using the ARG for evolutionary inferences. Abstract in Portuguese, Spanish and Chinese in the supplement doi.org/10.1093/gbe/ev…

The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

I've written about race, genetic ancestry, analyses of large biobanks, and human history gusevlab.org/projects/hsq/#… I'll summarize the key points here 🧵:

Reposting this criticism of All of Us and their use of ancestry labels