Babak Javid
@javid_lab
Infectious Diseases physician-scientist @UCSF| Fascinated by protein synthesis and TB. Occasional out of the box thinker. Bahá’í , father, husband. Own views.
Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages biorxiv.org/content/10.110…
Mycobacterium tuberculosis biology, pathogenicity and interaction with the host | Nature Reviews Microbiology nature.com/articles/s4157…
Thrilled to share our study @ImmunityCP how a TB-vaccine (BCG) and a fungi fragment (b-glucan) synergistically train neutrophils against cancers A big shout out to @lfjuradoz the entire team and collaborators @JosefowiczLab @AjithaT4 @E_v_a_Kaufmann authors.elsevier.com/a/1lJal_OR%7Ey…
2 of 2: Instead of activating a water molecule for hydrolysis, as previously thought, release factors induce a structural change in the transfer RNA, enabling its own 2’OH group to attack and break the bond, a universal process in all organisms. science.org/doi/10.1126/sc…
Here, we show that bacterial ribosomes—viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. This divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.celr…
Inspiring to hear @nickherbertcbe speak at the @QMUL Global TB symposium talking about cross-party, international global TB caucuses.
You know what HASN'T been tested in randomised, placebo controlled trials? All those supplements they try and sell you
Mycobacterium tuberculosis suppresses protective Th17 responses during infection through multiple mechanisms biorxiv.org/content/10.110…
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction: Immunity cell.com/immunity/fullt…
Fantastic meeting in Cape Town with the Collaboration for TB Vaccine Discovery. And very proud of postdoc @RBouzeyen giving a talk to the plenary as well as a poster!
Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical ... biorxiv.org/content/10.110… #biorxiv_micrbio
Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay | Science Translational Medicine science.org/doi/10.1126/sc…
Very cool study on forward genetics of Mtb in the context of immunization. TnSeq identifies genetic requirements of Mycobacterium tuberculosis for survival under vaccine-induced immunity rdcu.be/enT0l
Targeting malaria parasites within mosquitos through topical drugs. In vivo screen of Plasmodium targets for mosquito-based malaria control nature.com/articles/s4158…
Was such a pleasure to have contributed to this episode that was initially aired a year ago or so and just went out as an updated version. My take on "adaptive mistranslation" and how "errors in the right context and degree...can make it more resilient.."
Everyone makes mistakes. How do we learn from them? Lessons from the classroom, the Air Force, and the world’s deadliest infectious disease. link.podtrac.com/5zx7ktt4
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇
Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonic… pubmed.ncbi.nlm.nih.gov/40354525/
I went on WBUR today to talk about the grant terminations and the importance of basic medical research wbur.org/news/2025/05/1…