Jason Luke, MD, FACP
@jasonlukemd
Immunotherapy of Cancer • Melanoma • Phase I Clinical Trials • Lab: @ImmunoTiil • Disclosures: https://www.linkedin.com/in/jason-luke-11a38910/
🤯Three (!!!) new papers today in @ScienceMagazine on the application of generative AI for the de novo design of peptide/HLA binding molecules! Completely unique 3D structure and binding mode compared with natural TCRs and TCR mimics! Links to papers 👇
In vivo generation of panCAR (CAR-T/NK/Mφ) via immunotropic LNP-circRNA and boosting with circRNA vaccine effectively inhibits tumor growth and reshapes the tumor microenvironment in mice @CellRepMed cell.com/cell-reports-m…
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
1/11 Our study on subclonal immune evasion in non-small cell lung cancer has just been published in @Cancer_Cell cell.com/cancer-cell/fu…
Review @sigtrans_sttt: Pattern recognition receptors: function, regulation and therapeutic potential nature.com/articles/s4139…
🎙️ @diwakardavar and @jasonlukemd of @UPMCHillmanCC highlight exciting advances in drug development and other new IO data from #ASCO25 on a new episode of the #ASCODailyNews Podcast: bit.ly/4lx4hbu
Thrilled to share our paper on how mitochondrial complex IV remodeling can modulate TAM functions and promote anti-tumor immunity! with @ksimeono, @MFMich1, @Notorious_MHC, @rakez_krish, @delafuentelab, @andyjminn, @JHMLab and those not on X! Out now in @ImmunityCP 🎉
Online now: Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity dlvr.it/TLf6cn
Podcast alert! Enjoyed discussing #ASCO25 #Immunotherapy & #Melanoma data w @diwakardavar. Important studies that are advancing the field! dailynews.ascopubs.org/do/podcast-imm…
In vivo CAR T cell generation to treat cancer and autoimmune disease @ScienceMagazine Preview @Kyttaro_Therapy science.org/doi/10.1126/sc… @carlhjune @Haig_Ag science.org/doi/10.1126/sc…
De-coupling immune parameters and toxicity associated with IL-12 agonism @CellReports @KingOfPathogens cell.com/cell-reports/f…
(TPCPA), a proteomic resource that provides proteome-scale quantifications of 999 tumors across 22 cancer types in a unified manner, for discovering tumor biology, biomarkers, and therapeutic targets. cell.com/cancer-cell/ab…
For the immunologists still on X science.org/doi/10.1126/sc…
Available in #CancerScope! A 7-year study in The Lancet Oncology shows nivolumab + ipilimumab helps people w/ melanoma brain metastases live longer 🧠 CANCER Section Editor @jasonlukemd explains why this combination is now the go-to treatment acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn… @OncoAlert
📹Watch our #ASCO25 poster interview with @jasonlukemd discussing the SUPRAME trial comparing IMA203 (engineered TCR-T cell therapy) vs investigators choice in previously treated advanced #cutaneousmelanoma Abstract number | TPS2673 meetings.asco.org/abstracts-pres… #SkinCancer #SKcsm…
The CheckPoints are ready to party - join us tonight Sunday June 1 at Buddy Guys! Best party of #ASCO25 & all for the great cause of the @sitcancer Forward Fund that supports post-doc & trainee awards. See you tonight!!!
🔥 NEW Targets & Modalities at #ASCO25 – DevTherapeutics Spotlight 1️⃣ B7-H4 ADC (Emi-Le) 2️⃣ PD-L1/4-1BB bispecific (LBL-024) 3️⃣ PRAME TCR-T (IMA203) 4️⃣ CLDN6×CD3 mRNA bispecific 5️⃣ KRAS G12D inhibitor 6️⃣ WT1 oral cancer vaccine 7️⃣ [²¹²Pb] VMT-α-NET 8️⃣ IL-2α-bias fusion Ab 9️⃣…
Important publicly available resource from @TiroshLab @WeizmannScience in @NatureCancer The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution nature.com/articles/s4301… 124 single cell datasets across 40 cancers, >2800 samples.
Had the best time performing with @sitcancer’s band, #TheCheckpoints @AACR annual reception last night! #AACR25 🤘🎹 @RPachynski @jasonlukemd @ipimama123 @BReinfeld @sitcancer @DocsWhoRock
Rocking out with #TheCheckPoints, a band composed of cancer scientists including our very own @PatrickHwuMD, at the #AACR25 Annual Reception! 🎶
Time for the #AACR25 Annual Reception, featuring the #Checkpoints! Be there tonight 830 PM at McCormick Place West (Level 3) in the Skyline Ballroom (W375). We have a bunch of new tunes & rehearsal was great! @AACR @PatrickHwuMD @ipimama123 @BReinfeld
Review @AnnualReviews TNF/TNFR Superfamily Members in Costimulation of T Cell Responses—Revisited annualreviews.org/content/journa…