Jake June-Koo Lee
@jakelee0711
Physician Scientist @CompOncMSK and Thoracic Oncologist @MSKCancerCenter Historian of Cancer Genomes | Chromosome Biology | Therapy Resistance
Today marks a meaningful milestone -- I am starting as a lab investigator @CompOncMSK and thoracic oncologist @MSK_DeptOfMed, focused on improving treatment through a deep understanding of cancer evolution. I'll soon be looking for fellow travelers on this mission. Stay tuned!
Congratulations to Dr. Mark Kris @MSKCancerCenter for being named a Giant of Cancer Care for his many contributions to advancing the field of thoracic oncology! @OncLive #lcsm onclive.com/view/giants-of… via @onclive
1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…
A beautiful story by @FaltasLab on mutational processes in urothelial cancers. Elegant demonstration of fitness benefit of CCND1 ecDNA during chemotherapy. We will learn a lot from WGS of clinical samples re interactions btw treatment and cancer genomes. Congrats to the authors!
🚀Big News! Excited to share our work “The Interplay of Mutagenesis and ecDNA Shapes Urothelial Cancer Evolution” published in @Nature! nature.com/articles/s4158…
So glad that I was able to participate in this wonderful multi-year team effort! #SPECIFICancer @CancerGrand @TheMarkFdn
We’re in Barcelona for the final review meeting of the SPECIFICANCER @CancerGrand Challenges team, which we fund with @CR_UK. Since 2019, the team—which spans 9 institutions—has explored why most gene mutations only cause cancer in some tissues. themarkfoundation.org/portfolio/the-…
So excited to be here with great people who will lead medicine and science! Thanks for @BWFUND for this opportunity. #CAMS #2024BWF
🗣️11 of MSK’s talented scientists & clinicians were selected to appear in an off-Broadway musical called “Lifeline." The show tells the story of the discovery of penicillin, weaving in “superbugs,” romance, & urgent messages about antibiotics, all set to music. A preview ⬇️
Fusion variant-specific tumor suppressors in ALK+ lung cancers. SETD2 inactivation conferred a larger impact on tumorigenesis in the context of EML4-ALK v3 (fusing exon 6 of EML4 and exon 20 of ALK) than v1 (e13-e20).
Amazing collaboration between @EmilyShuldiner and @Alberto_DiazJ using somatic genome editing to model 60 different genotypes of EML4-ALK lung cancer. Genetics say that Variant 1 and Variant 3 should be considered distinct oncogenes @SotilloLab biorxiv.org/content/10.110…
Unexpected role of Fanconi anemia pathway in chromothripsis. It’s just incredible learning experience to follow the experimental papers since the initial description of chromothripsis in 2011. Amazing biology.
🚨 Excited to share our latest paper in @CellCellPress identifying how under-replicated chromosomes in micronuclei become shattered by the Fanconi anemia pathway during mitosis. This work was led by @UTSWGradSchool student @JustinEngel17. 🧵 (1/13): cell.com/cell/fulltext/…
Wonderful opportunity to interact with the thought leaders of EGFR+ lung cancer. The inaugural meeting in 2019 motivated me to come back to clinic.
🎉 Ready to elevate your # LungCancer #Research skills & career? Join us for #EGFRSummit in collab w/@egfrresisters & @CEC_onc Submit your abstracts by Sept 30 & gain valuable career insights ➡ ce.ceconcepts.com/EGFR24 @jillfeldman4 @ZPiotrowskaMD #LCSM #EGFR
We spent two days in the mountains discussing how cancer genomes become such a chaotic and rearranged mess. Thanks to the participants, my fellow co-organizers @isidrolauscher and Titia de Lange, and @ForbeckForums for bringing us together in Aspen, Colorado!
Peter Campbell leaves the Sanger Institute at the end of the year to become Quotient's CSO. A mentor and one of my favourite scientists. His foundational, profound and creative contributions to cancer genomics and somatic evolution have truly shaped those fields. [1/7]
Academic co-founder, Peter Campbell, Ph.D., is joining the Quotient team as CSO. We look forward to advancing the first ever #SomaticGenomics platform under his leadership. Read more: bit.ly/3YBCkqS
Why ALK fuses w/ EML4 in lung cancers and not often w/ KIF5B? We never see TMPRSS2-ALK and what's the biology behind? An exciting paper from @chiarlelab led by translocation expert @TC_Cheong. A major step forward to understand the mechanisms of SVs! nature.com/articles/s4146…
Awesome opportunity to work with the rising star of this field in an exciting team!
Hello Xverse, we're on the hunt for a postdoctoral fellow to study cellular and systemic metabolism with a quantitative, multimodal toolkit. Is this you or someone you know and love? Reach out!
Please read, send feedback and retweet link to free full-text work on how a variant cell cycle coordinates differentiation of multi ciliated cells: rdcu.be/dJmnv