Mike Spencer Chapman

So pleased to have the paper out, available here: nature.com/articles/s4158… For me this was discovery science as I had always hoped it would be. Unpredictable, a lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below 🧵

Thank you HaemStar! It was a great day, lots of exciting & motivating talks - really recommend future events to all haem trainees/ those interested in choosing haem training

Congratulations on your elegant paper! It's great to see #LesionSegregation being identified in other settings, and used as the basis for your interesting and important biological insights into mutagenesis, cancer biology, and evolution...

In a paradigm shift in how we view mutations, researchers uncover forms of DNA damage in healthy cells that can persist unrepaired for years, published on @Nature. nature.com/articles/s4158… By @doctor_msc, @TimCoorens, Peter J. Campbell, et al. @Cambridge_Uni, @sangerinstitute

DNA damage can go unrepaired for years, which can create multiple chances to generate harmful mutations that could lead to cancer 🧬 Read more about this research, and how it changes the way we think about mutations ⤵️ sanger.ac.uk/news_item/dna-…

📰 Some forms of DNA damage linger unrepaired in healthy cells for years, according to a @Nature study led by Dr Mike Spencer Chapman @doctor_msc at BCI and @sangerinstitute.  Read more👉 bit.ly/40wJX2f The findings could inform our understanding of cancer development.

Building on our discovery of #LesionSegregation, @doctor_msc and colleagues from @sangerinstitute find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells” nature.com/articles/s4158…

Fascinating stuff! Lots to learn about these structures. Congratulations Chris! 🎉