Dziugas Sabonis
@d_sabonis
PhD student @VU_LT
Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential biorxiv.org/content/10.110…
Research from Renee Chang @reneechang explains how viruses disrupt His-ADPR immune signaling. Kranzusch lab (kranzuschlab.med.harvard.edu), @SorekLab, @eigie111, @Nature nature.com/articles/s4158…
Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…
Registration for our PhD / postdoc course 'Fundamentals of Basic and Applied Phage Biology' is now open! See you in Lund May 12-16! ndpia.se/events/fundame…
Our NAD-reconstitution story is finally published in @nature rdcu.be/dU5AQ Thank you to all co-authors, especially to @hadarsamra, @FrancoisRousset, Elena Loseva, @ErezTzvi, @AdiMillman, and everybody in the @SorekLab for their help and support.
"Little pigeons can carry great messages🕊️" Phages produce NAD+ by one-step reactions from nicotinamide (all other organisms need at least two) and protect themselves against multiple bacterial immune systems. Check out our new preprint - biorxiv.org/content/10.110… A thread below⬇️
More details on the discovery, led by super talented @IlyaOsterman, are in the thread below x.com/SorekLab/statu…
Preprint: Phages reconstitute NAD+ to counter bacterial immunity tinyurl.com/NADPD Many bacterial immune systems degrade NAD+ to deplete the cell of energy, halting phage replication Ilya Osterman now discovered that phages can rebuild NAD and overcome defense
Exited to announce the publication of our work showing that activated type I Thoeris SIR2 effector ThsA forms helical filaments in @Nature. Thread below nature.com/articles/s4158…
Our take on Thoeris type I system. Glad to see these right-handed spirals in (N)nature. 🧬 This work was led by Giedre Tamulaitiene (@eigie111) in collaboration with @SorekLab. nature.com/articles/s4158…
