James Hadfield
@coregenomics
Developing ctDNA strategy & Epigenomics methods at @astrazeneca. NGS & Dx expert and 'omics fan. Developer of @Enseqlopedia, ex-@CRUK_CI. Views are all mine.
"RNA-Seq: the teenage years" our review in @NatureRevGenet is now online. Thanks to my co-authors, to everyone who's work we cited and to all of you using RNA-Seq. Enjoy! nature.com/articles/s4157…

This is what success looks like, folks!
Hopeful that because the front cover has a DNA strand we’ll see more on genomic medicine As someone who is involved in sorting this out in our region, I’m hopeful that we’ll be able to deliver tangible benefits for patients (with the right funding!! 😂)
🚨 Hot off the press... the 10 Year Health Plan. More details tomorrow.
I saw the title and said “Stupid Flanders!” - then saw the author had gone above and beyond with the intro #eshg2025
Really good read! I always just think about this from a customer’s point of view. I learned a lot! Thanks! @illumina
Thinking through Illumina...what killed their reliable growth algorithm, and what happens next. (Link in next post)
🧧🧧🧧🧧 So another exciting finding for the weekend before I go on vacation. *FFPE Ligation Sequencing for ALL!* For a long while it was thought that ligation (i.e. native DNA) sequencing on @nanopore was difficult, if not impossible, because the DNA blocks the pores and it…
65,000 UK companies are unlawfully hiding their beneficial owner. We've just published an interactive map showing them all. Thread:
Sound up please. Meet Maj Gen Jeannie Leavitt. She was the FIRST EVERY female fighter pilot. The women beating unqualified Secretary of Defense Pete Hegseth, has ordered the removal of every image of Maj Gen Leavitt removed from the Pentagon. Can someone tell me how this…
📺Missed it last night? Catch Prof Jason Carroll on @BBCLookEast discussing Cambridge’s global science community. 🌍🧬 "We want to cure cancer, we need the best and brightest people to do that, and we don't really care where they come from." bbc.co.uk/iplayer/episod…
A new twin study has strengthened the link between tattoos and cancer risk. For tattoos larger than a palm: 🔺 137% higher risk of skin cancer (HR = 2.37) 🩸 173% higher risk of lymphoma (HR = 2.73) Let’s break it down 🧵 1/11
"Passage de Vénus" is a series of photographs of the transit of the planet Venus across the Sun on December 9, 1874. They were purportedly taken in Japan by the French astronomer Jules Janssen and Brazilian engineer Francisco Antônio de Almeida using Janssen's 'photographic…
Another superb contribution here - if you missed today’s Roche call well worth a look.
Roche Xpounds on New Sequencing Technology - my coverage of the new Roche SBX sequencing technology omicsomics.blogspot.com/2025/02/roche-…