Ayan
@ayanobacter
PhD in Synbio, Entrepreneur, Open Science, Researching and Writing About Futures and Frontiers
My new post is out 🧬 If you're not paying attention to the DNA sequencing landscape, you should be. Illumina's 80%+ market share is finally facing some highly innovative challengers. The next frontier emerges: from how do we read DNA to how will we interpret all of this new data
Our @ScienceMagazine paper is out! Discovered how tRNA-derived small RNA (tsRNA/tDR) protects kidneys via RNA autophagy. science.org/doi/10.1126/sc… Huge thanks to @SaumyaDas_Lab and all our amazing collaborators! Excited for the therapeutic potential ahead! @MGHanesthesia @mghcvrc
Sometimes I wonder if my ideas/ambitions are too wild And then I remember people had the audacity to say humans will fly And now I can look up and see an aluminum tube carrying hundred of people soaring through the clouds above me It’s absurd and inspiring
La-Proteina sounds like a new fashion house elevating foundational generative protein models to serve backbone and side chains all at once this is structural protein couture
Hybrid explicit-latent flows are the new foundation models for protein structures. La-Proteina shows that one network can design 800-residue, all-atom structures and sequences, then perform well at motif scaffolding. Read more: nvda.ws/4nOjBSL
📢📢 "La-Proteina: Atomistic Protein Generation via Partially Latent Flow Matching" Fully atomistic. Partially latent. Structurally precise. Entirely generative. w/ @tomasgeffner*, @DidiKieran*, et al. 📜 Project page & paper: research.nvidia.com/labs/genair/la… 🧵 Thread below... (1/n)
The cosmologist in me loves that there is a cosmological bound on how assembled a single structure can be in a universe devoid of life (clearly our universe is doing much more interesting things, at least on this planet)
Maybe there isn’t a funding/talent gap Maybe there’s a creativity gap We can’t keep saying “not enough people are working on X space” What if a lot of people are working on it & it’s still not thattt great? The gap = creativity Be an entrepreneur tackling the creativity gap
Science is in crisis. When we’ve faced challenges in the past, scientists have retreated to the status quo. It’s time for extraordinary metascience.
How are the 10,000+ rare diseases affecting 1 in 10 Americans NOT a national priority?
Marty Makary FDA Commissioner discusses the Commissioner's National Priority Voucher Program on CNBC: What qualifies as a national priority? 🔹Large unmet public health need. Would like to see: - cure for T1 diabetes - more cancer therapies for stage 4 metastatic disease -…
Still thinking about 125 million bioluminescent algae, glowing in living couture, draped across a dancer’s body, a flowing vision that painted the dark Paris runway with light that breathes Again: the overlooked innovation frontier for biology is where it intersects with art
You can tell someone’s smart by how well they simplify things, not complicate them.
3 things I love here: Open source Programmable protein design And BAGEL(s) ofc
🚨 Excited to share the first major project of my PhD: BAGEL, a modular, model-agnostic, fully customizable Python framework for programmable protein design 🧬🥯 Code (BAGEL) 💻: github.com/softnanolab/ba… Code (boileroom) ⚙️: github.com/softnanolab/bo… Preprint 📜:…
I was today years old when I learned Sir Peter Jackson, director of Lord of The Rings franchise, has one of the largest private moa bone collections And is now putting in 15 million to fund their de-extinction with Colossal! Is this…bespoke luxury bioengineering
NEW PROJECT: We’re working to bring back the South Island giant moa, one of the largest birds to walk the Earth. Gone for 600 years, its legacy still echoes. From ancient DNA to artificial eggs, this project could reshape the future of bird conservation.