Aya Abdelsalam Ismail
@asalam_91
Co-founder and CSO @guidelabsai Former Research Scientist @prescientdesign @Genentech, PhD @umdcs
.@asalam_91 dropping some knowledge and insight
booming
Come say hi at my #AISTATS2025 poster tomorrow! 📍 Poster Session I #83 🕒 Sat, May 3 at 3pm Semiparametric Conformal Prediction uses copulas and the one-step estimator to build efficient conformal sets over multiple response variables. Joint work w/ Rob Tibshirani, @kchonyc
📢 Excited to present our poster at the #ICLR2025 @gembioworkshop! I'll be introducing TherAbDesign - a novel, sequence-based framework that efficiently optimizes antibodies toward therapeutically relevant biophysical properties. [1/4]
Interpretable Lobsters at #ICLR2025 🦞 🦞 Come by poster #504!

I will be presenting this work tomorrow at #ICLR2025 at 10 am stop by to know how to build protein language models and use them to design proteins with new properties!
[1/n] Does AlphaFold3 "know" biophysics and the physics of protein folding? Are protein language models (pLMs) learning coevolutionary patterns? You can try to guess the answer to these questions using mechanistic interpretability. But the thing is, more often than not, we know…
I will be @iclr_conf this week! If you are there drop me a message I would love to catch up and maybe talk about interpretable foundation models 😉
Lab-in-the-loop therapeutic antibody design At @PrescientDesign @genentech we have spent 3+ years reimagining drug discovery. We built a machine learning system to design and execute experiments. Here's how it works and what we can do 🧵 1/
doing any data loading in Torch? i wrote a beginner's guide (as a beginner) to Torchdata 0.10.1, the first version with data Nodes. (cc' @ho_andrew) i already started using it. it's great! this is also @PrescientDesign's first blog post :D medium.com/@prescientdesi…
Next Tuesday, 2/4 @ 4 pm EST, @asalam_91 and @nc_frey will present "Concept Bottleneck Language Models" Paper: arxiv.org/abs/2411.06090 Sign up on our website to receive Zoom links!
Exciting news! I've left Prescient to co-found @guidelabsai an interpretability startup with @juliusadml. We're building interpretable foundational models to address key AI challenges. While I loved my time at Prescient, I'm thrilled to build something I'm very passionate about!…
Research Intern position @PrescientDesign in Switzerland 🇨🇭💊 join our Frontier Research team in 2025! Apply now or share with anyone who might be interested: roche.wd3.myworkdayjobs.com/roche-ext/job/…
Curious how causality can boost generative models in low-data regimes? ✨ Let's chat! Swing by our poster at #NeurIPS2024 today - Session 1 East, 11am PT. We show how PropEn works across fields from engineering solutions to designing functional therapeutics!
Excited to share our new preprint 🥳🥳 Implicit guidance with PropEn: Match your data to follow the gradient 🔗 arxiv.org/pdf/2405.18075 Joint work with @loukasa_tweet, @kchonyc, @GligorijevicV at @prescientdesign & @genentech