Amy Wang
@amywang01
Sr ML Scientist @PrescientDesign working on problems at the intersection of strxbio, physics, and machine learning. prev @Stanford @MSFTResearch @MIT
come say hi today at the @gembioworkshop from 4:20pm-5:20pm, hall 4! paper link: openreview.net/forum?id=oOBMi… workshop: iclr.cc/virtual/2025/w…
📢 Excited to present our poster at the #ICLR2025 @gembioworkshop! I'll be introducing TherAbDesign - a novel, sequence-based framework that efficiently optimizes antibodies toward therapeutically relevant biophysical properties. [1/4]
[1/n] Does AlphaFold3 "know" biophysics and the physics of protein folding? Are protein language models (pLMs) learning coevolutionary patterns? You can try to guess the answer to these questions using mechanistic interpretability. But the thing is, more often than not, we know…
1/🧬 Excited to share PLAID, our new approach for co-generating sequence and all-atom protein structures by sampling from the latent space of ESMFold. This requires only sequences during training, which unlocks more data and annotations: bit.ly/plaid-proteins 🧵
As part of our commitment to open science, I'm excited to share that an alpha version of our protein design code is available! Check out the tutorials to learn how to designs proteins yourself with guided discrete diffusion, just like the pros github.com/prescient-desi…
Very nice talk by @kchonyc at #ICLR2024! TIL feature attribution can be used in protein synthesis to identify regions to mutate based on target properties of interest 🔍
I am hiring a #machinelearning scientist on my team @Prescient @genentech please apply if interested in geometric deep learning, generative modeling, de novo protein engineering, and want to be on the interface of structure/ML/experiments/engineering roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
#MotorsInQuarantine will feature @amywang01 from @Dunn_Lab and @MarkDodding. Join us tomorrow to discuss how actin links to cell-cell adhesions and kinesin-1 is folded into the lambda particle when not busy transporting cargo along microtubules. mechanochemistry.org/whatson/MiQ/
New paper! @amywang01 describes the probable mechanism by which alpha-catenin, and likely related proteins, makes a force-sensitive catch bond with F-actin. Also, intriguing clues about the origins of cooperative actin binding. Congrats Amy! elifesciences.org/articles/80130