Arpaia Lab

New paper in collab w/ @tdanino lab out today in @Nature! @andrewredenti, @JongwonIm8158 and team engineer probiotic E. coli as cancer vaccines to stimulate tumor neoantigen–specific immunity and kill solid tumors! @Columbia_MI @ColumbiaBME @columbiacancer nature.com/articles/s4158…

The Arpaia Lab is currently recruiting for a Staff Associate I position 🧑‍🔬. Please share the following job description and application link with anyone you believe would be interested. Thank you! apply.interfolio.com/167245

Excited to share a preprint of our latest study in collaboration w/ @tdanino's lab – synthetically engineered E. coli expressing CXCL13 synergizes with PD-1 blockade to amplify antitumor antibody responses and inhibit bladder cancer growth. @Columbia_MI biorxiv.org/content/10.110…

Congrats @li_fangda and team! Another great collab w/ @tdanino's lab out today in @SciImmunology! Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. @Columbia_MI @ColumbiaCMBS @columbiacancer science.org/doi/10.1126/sc…

New paper in collaboration w/@arpaialab out in Nature today! @andrewredenti, @JongwonIm8158 and team engineer E. coli Nissle probiotic as cancer vaccines nature.com/articles/s4158… @ColumbiaBME @columbiacancer. Congrats all!!

In this review, Loffredo, Savage, Ringham, & Arpaia @arpaialab @Columbia_MI examine interactions between Treg cells and tissue-resident non-immune cells—in the context of tissue repair, #fibrosis, and #cancer—and discuss areas for future exploration. hubs.la/Q02v9wxT0

Congrats 🥳 @Thomas_M_Savage and team on a study published today in Immunity demonstrating Treg-derived amphiregulin promotes NASH-induced liver fibrosis and glucose intolerance! 🧑‍🔬🍔🍟 @ColumbiaCMBS @Columbia_MI @cudldrc @MD_PHD_CUMC_VPS tinyurl.com/2ptfr8wf

Excited to share our new preprint! We program probiotic bacteria to create a next generation anti-tumor vaccine that stimulates tumor neoantigen-specific immunity to control and eradicate solid tumors @ColumbiaCMBS @ColumbiaBME. biorxiv.org/content/10.110…

Check out this beautiful new study on the mechanism of DNA double-strand break resection initiation from the lab of @Columbia_MI Professor Lorraine Symington, published this week in @MolecularCell!!! 🧬🧑‍🔧👇 doi.org/10.1016/j.molc…

This #InternationalWomensDay, the HICCC celebrates all of our doctors, patients, researchers, and staff, who have worked together to advance equitable cancer care for all. #EmbraceEquity #IWD23 #IWD @ColumbiaMed @nyphospital

Excited to share our work published today in @ScienceAdvances! @Thomas_M_Savage with @arpaialab and @tdanino lab members engineer bacteria to intratumorally release chemokines that recruit T cells and DCs into tumors, activating anti-cancer immunity. tinyurl.com/ycxf3nss

Excited to see our work featured on the March cover of @JExpMed! Kaiser and @arpaialab team (@Columbia_MI) show Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells in #influenza infection, promoting alveolar regeneration. tinyurl.com/2pb87dv7

Excited to share our work from @LucilleRankin and @arpaialab team in @Columbia_MI! In brief, dietary tryptophan deficiency promotes expansion of intestinal RORγ+ Tregs in a microbiota dependent manner.

Our March cover shows a lung section of a mouse infected with influenza virus (red) with Tregs (green) and stained for secreted extracellular matrix proteoglycan Agrin (white). From Kaiser et al @arpaialab (bit.ly/3KMFS2l). Read JEM’s March Issue: bit.ly/3IxZe8A

Excited to share our work from my time at @Columbia_MI. In brief, dietary Tryptophan depletion rather specifically promotes RORγ+ Treg expansion in a microbiota dependent manner. Thanks to all involved 🙏❤️ cell.com/cell-reports/f…

Check out this exciting work from @Columbia_MI student Kate Kaiser in @arpaialab, recently published in @JExpMed!

New publication from our lab out in @JExpMed! Kaiser and team show that, during #influenza virus infection, Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells, promoting alveolar regeneration. rupress.org/jem/article/22…

Kaiser, Arpaia et al. @arpaialab @Columbia_MI show that, during #influenza virus infection, Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells, promoting alveolar regeneration. bit.ly/3YAx58o #InfectiousDisease #MucosalImmunology