anna brogan
@apbrogan
PhD student into bacteria & coffee. Rudner lab @harvardmed. @penn_state alum.
Very happy to share that a large part of my thesis work is out today: B. subtilis uses the second messenger c-di-AMP to modulate its turgor pressure in response to the state of its cell envelope. nature.com/articles/s4156…
Impressive work on a classifier to distinguish likely true AF-multimer predictions from false positives. A bacterial classifier next please!
My work in Johannes Walter’s lab on developing a classifier to score AF-multimer predictions (alongside a large scale screening effort) is out as a preprint now! biorxiv.org/content/10.110… @Johanne23743184
The SubtiWiki Paper of the month for June 2025 has been selected! Congratulations, @apbrogan @ @harvardmed @NatureMicrobiol subtiwiki.uni-goettingen.de/wiki/index.php…
Out Now! Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis bit.ly/3FZ4jJY #CyclicDiAMP #BacterialCellWall #Microbiology
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. cell.com/molecular-cell…
SAVE THE DATE ‼️ 📆 📢 BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there. Registration and scholarship applications open next week.
Angelika Gründling’s work from her sabbatical in the Bernhardt-Rudner labs is out! She came with the goal of finding the missing G+ phosphatidylglycerol phosphate phosphatase and found it with time to spare. I can also highly recommend her as a bay mate! pnas.org/doi/10.1073/pn…
Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 biorxiv.org/content/10.110…
The Bartlett Lab is open for business at the Wadsworth Center! We study pathogens with "unusual" shapes (balls & corkscrews) to find vulnerabilities in their growth plans, and learn how bacterial shape impacts infection. We are hiring... join us! wadsworth.org/research/labor…
I had a lovely time getting to hear some fantastic talks and share my own work at the John Innes Centre yesterday! So much exciting microbiology happening.
We’re excited to be kicking off our Early Career Microbiologists Symposium 2024 🌟 Following an introduction from Graham Moore, JIC Director, our morning session is chaired by @SusanSchlimpert and begins with a talk by Anna Brogan @harvardmed
Make publication ready figures from your #AlphaFold PAE files. Works on multimer and AlphaFold 3 files. Customize colors and export as an SVG for editing in illustrator! thecodingbiologist.com/tools/pae.html
Interactively browse all the predicted structures here: predictomes.org/view/acidicpat…
Excited to share that our new preprint is out! We used #AlphaFold multimer to screen 7000+ nuclear proteins to find new nucleosome acidic patch binders. Great collaboration between @FrogWalterLab and @LucasFarnung. biorxiv.org/content/10.110…
another great year for @BostonBacteria! huge shoutout to all of the presenters, the OC, and to @LaurentDubois99 and Molly Sargen for running the whole show (& for incredible crisis management when BBM went dark)

Riding the #AlphaFold3 wave with a new analysis tool. It’s super new/unpolished, but would love to get community feedback! Extract and filter residue level interaction data from your AF3 server prediction zip files! Try it here: predictomes.org/tools/af3/
Super excited to be releasing AlphaFold 3 today, developed by @IsomorphicLabs and @GoogleDeepMind: our next generation AI model for predicting the biomolecular structures and interactions of proteins, DNA, RNA, small molecules, and more: bit.ly/44yfaCw 1/
Bacillus subtilis uses the SigM signaling pathway to prioritize the use of its lipid carrier for cell wall synthesis @PLOSBiology by @ianroney and David Rudner journals.plos.org/plosbiology/ar…