Aino-Maija Leppä

@amleppa

Current | Postdoc at Francis Crick Institute at @SwantonLab ••• Previous | PhD at DKFZ with Andreas Trumpp @hi_stem_lab

Joined April 2022

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Aino-Maija Leppä Retweeted

HI-STEM - Cancer and Stem Cells in Heidelberg@hi_stem_lab · Jun 12, 2023

Excited to announce: International Heidelberg Symposium on Stem Cells and Cancer on Sep 10-12, 2023 @DKFZ. Worldwide opinion leaders present latest data on cancer stem cells, tumor heterogeneity, therapy resistance & more! Registration for FREE @ stem-cells-cancer.de. #SCC2023

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Aino-Maija Leppä Retweeted

Oriol Pich@oriol_pich · Apr 24

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more nejm.org/doi/full/10.10…

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HI-STEM - Cancer and Stem Cells in Heidelberg@hi_stem_lab · Feb 18

🚨 Paper out in Nature 🚨 Amazing news from the Trumpp Lab @HI_STEM_lab performed by Vera Thiel @VT199104, Simon Renders @SimonRenders and Jasper Panten! Discover how tumors interact with nerve cells! 👇👇👇 nature.com/articles/s4158… #CancerResearch #Neuroscience

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Constantin Ahlmann-Eltze (@const-ae.bsky.social)@const_ae · Jan 3

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳 nature.com/articles/s4158… LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space. Some highlights⬇️

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Constantin Ahlmann-Eltze (@const-ae.bsky.social)@const_ae · Sep 20

There's a lot of excitement about foundation models and their ability to learn biology 🧬💻 But current tools for perturbation prediction perform worse than simple linear models! We need more careful benchmarking to make progress. biorxiv.org/content/10.110…

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Alexander Waclawiczek@AlexWaclawiczek · Feb 20, 2024

Interested in the "Arms-Race" against therapy resistance in Acute Myeloid Leukemia? Read our perspective just published in molecular oncology. febs.onlinelibrary.wiley.com/doi/10.1002/18… @hi_stem_lab @amleppa @SimonRenders

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Aino-Maija Leppä Retweeted

Constantin Ahlmann-Eltze (@const-ae.bsky.social)@const_ae · Feb 10, 2024

Just uploaded a new version of the LEMUR manuscript biorxiv.org/content/10.110… 🎉🥳 LEMUR disentangles observed and latent factors of multi-condition single-cell data and finds groups of cells with consistent differential expression for each gene. Details on the changes ⬇️

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Aino-Maija Leppä Retweeted

Constantin Ahlmann-Eltze (@const-ae.bsky.social)@const_ae · Apr 10, 2023

Incredibly proud to see our benchmark of single-cell preprocessing methods finally published 🥳🥳🎉 We show that despite its theoretical limitations, no other transformation consistently outperforms log(y/s+1). All details at nature.com/articles/s4159… and github.com/const-ae/trans…

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Aino-Maija Leppä@amleppa · Mar 10, 2023

Thrilled to share some of the exciting results from my PhD from an amazing collaboration with @AlexWaclawiczek @SimonRenders at Trumpp Lab @hi_stem_lab 🎉🎉

HHI-STEM - Cancer and Stem Cells in Heidelberg@hi_stem_lab · Mar 10, 2023

Trumpp lab @DKFZ is thrilled to announce our latest story in @CD_AACR Amazing collab between @AlexWaclawiczek, @amleppa + @SimonRenders combining basic + clinical research with Tim Sauer and @LabTidow. #AML #Venetoclax #PrecisionMedicine #LeukemiaStemCell (1/12)

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