Han Altae-Tran
@altaetran
Fascinated by all things science. Protein designer (aka postdoc) at UW | PhD BE, MIT | MS EE, BS Math, Physics, Stanford
Our latest work exploring ultra rare CRISPR systems with new big data algorithms has been published by @ScienceMagazine! @zhangf @soumya_kannan12. This thread will unwrap how we found needles in a haystack of metagenomes. Let's dive in! (1/8) doi.org/10.1126/scienc…
What's neat is that, using a bioinformatics approach, Han @altaetran et al. recently found putative examples of even more TnpB domestication events, including associations with transcriptional activators! Maybe we'll need a new name for those 😁 doi.org/10.1073/pnas.2…
A new preprint from @shsternberg @SternbergLab shows that TnpB, the ancestor of CRISPR-Cas12, has been naturally co-opted for RNA-guided transcriptional regulation of bacterial flagellin systems! doi.org/10.1101/2023.1…
CRISPR defense now known to target mRNAs in ribosomes - the source of all proteins in the cell - in order to prevent viruses from making proteins. Truly amazing! science.org/doi/10.1126/sc…
The clustering algorithm FLSHclust identifies previously unknown CRISPR-linked systems using a mining approach with great potential for advancing biotechnology development in both research and the clinic. #NBThighlight science.org/doi/10.1126/sc…
Check out our latest work on a new algorithm for protein clustering and the discovery of new CRISPR systems! More on this soon. So grateful to have this work published by @ScienceMagazine !
Using a new algorithm called FLSHclust, researchers have revealed rare and previously unknown #CRISPR-Cas systems. The approach and results provide novel opportunities for understanding the vast functional diversity of microbial proteins. scim.ag/4W6