Adith Arun
@aditharun_
md candidate @yalemed, writing at http://aditharun.com, prev @delfidiagnostic @ibmresearch and math @johnshopkins
Nick Sleep’s letters are amazing, some of the clearest thinking I’ve read igyfoundation.org.uk/wp-content/upl…
Intel, the home of Moore's Law, for the first time in history, is evaluating if it will continue at the leading edge. From its 10-Q "However, if we are unable to secure a significant external customer and meet important customer milestones for Intel 14A, we face the prospect…
52 or 53 of patients given onvansertib in the Ph2 JCO study from Oct 2024 discontinued treatment. STRIKING. ~20% of patients dosed with onvansertib discontinued out of choice/adverse effects.
a core tension in applying "virtual cell" models to therapeutic development is the mismatch between the scale at which we measure biology and the scale at which we intervene. we often measure at the cell level (eg single-cell RNA-seq), but we treat at the tissue or organ level…
I just realized I walk with my anterior tib always mildly flexed which prevents my ankle from going through its full range of motion. Probably contributes to my stiffness. It might have started subconsciously after turning my ankle so many times playing soccer/basketball
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
There was a kid I knew growing up who wanted to make films and spent basically all his time on it. He was good and had his stuff shown at a local theater. I remember the theater being pretty full when I went. It was great work, and he clearly loved it. I’m not sure if others…
DMD online forums presumably composed of parents of patients and caregivers is not that happy on the whole that $srpt has been pulled. They seem to believe possible benefits > risks (including premature death). There is a very valid medical ethics discussion here that should be…
One of my hypotheses is that oxygen extraction deficiencies are very common in the population motivated by my observation of iCPET and R heart cath studies of patients with unexplained dyspnea. There have been a number of new papers in mitochondrial science the past few days.…
Who is the Pelosi equivalent for single or few asset biotech companies? @PelosiTracker_