Adam Glaser
@adam_k_glaser
Developing hardware + software tools for large-scale imaging @AllenInstitute for Neural Dynamics.
How do you image the large and the small at the same time? We developed new 🔬 technology to image centimeter-scale specimens - including whole mouse brains 🧠 - with diffraction-limited resolution and without sectioning. #mesoscale #imaging biorxiv.org/content/10.110… 🧵 (1/n)
Very exciting updates from @Andrew_C_Payne and @E11BIO. Excited to see future developments and progress and how imaging/microscopy advances can help push this to the exascale!
E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵
First 3200 MP images from the LSST at the Vera C. Rubin Observatory! nature.com/articles/d4158…
The MOSAIC reconfigurable microscope by @Eric_Betzig et al is finally out! MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics: biorxiv.org/content/10.110…
High-throughput line scanning confocal microscopy biorxiv.org/content/10.110…
We are excited to share our development of a new 10X lens with NA=0.50 over a 7.2 mm FOV and a 35 mm working distance (water), fully corrected from 400-850 nm. This lens will power our upcoming ExA-SPIM "2" and is available for dissemination - please get in touch if interested!
To look into: a Python alternative to ZEMAX... github.com/HarrisonKramer…
New review out on imaging 3D cell cultures. Congratulations to Huai-Ching and @jonliu123 on leading this excellent new review! nature.com/articles/s4159…
Curved light-sheet microscopy nature.com/articles/s4156…
Thermal Lensing Effects in Light-Sheet Microscopy arxiv.org/abs/2504.02969
I’m catching up on good news. THE LIBERATORS is a 2025 Pacific Northwest Book Award Finalist for Fiction. Thanks to @pacificnwbooks1 and congrats to @BillyRayB, Anne de Marcken, Tara Karr Roberts & the other winners!
Sound-sheet microscopy - in this study, we introduce nonlinear sound-sheet microscopy (NSSM), a method to image targeted biological functions across cubic centimeters of opaque living tissue. science.org/doi/10.1126/sc…
Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue biorxiv.org/content/10.110…
🚀 We are looking for Image Data Scientists to join our mission to advance connectomics towards whole brain scale for humans and other mammals (1/3) 🚀
New 410 MP camera sensor coming in 2025 from Canon global.canon/en/news/2025/2…
Software folks. What web based multi scale image viewers exist? Aware of neuroglancer, viv, openseadragon, zoomify, are there others?
Okay, here is the belated Xmas present for OPM and SCAPE drivers. Deliberate aliasing and recovery to speed up 3D acquisition. biorxiv.org/content/10.110…
First imaging experiment with our new ExA-SPIM software… fingers crossed for no dropped frames or crashes! 😅
Christmas came early. Thank you to @ximeagmbh for sending this prototype camera with the upcoming 246 MP Sony IMX811 sensor! Excited to start testing.
#拡散希望 当研究室からNature Protocols誌に新しい透明化技術論文を発表。ハイスループットな透明化・染色・解析パイプラインが可能に。秋山さん、松本さん達の仕事です。おめでとうございます。興味がある方は、PR→ riken.jp/press/2024/202… 論文→nature.com/articles/s4159…