Zondlo Lab
@ZondloLab
Chemical biology/bioorganic chemistry and other such shenanigans. Ruthless multidisciplinarians.
Today’s Organic 1 class covered diastereomers, resolution, and asymmetric catalysis. The Chemistry @NobelPrize #chemnobel fit in perfectly. So I ended class with a song. With apologies to @DollyParton: “Proline” sung to Jolene. Congratulations @ListLaboratory @MacMillan_Lab!
Electronic Control of Polyproline II Helix Stability via the Identity of Acyl Capping Groups: the Pivaloyl Group Particularly Promotes PPII (Megh R. Bhatt and Neal J. Zondlo @ZondloLab) onlinelibrary.wiley.com/doi/10.1002/ch…
Microsoft, all we’re asking for in Word is for the ability to place or subtly move individual graphics without playing random reformatting roulette, with graphics and text flying everywhere, never to return whence they came.
Check out our work on protein editing!
A pair of split inteins—small protein segments that can undergo a self-sustained protein splicing reaction—enables endogenous protein editing in living mammalian cells, according to a new study in Science. 📄: scim.ag/3ENypj9 #SciencePerspective: scim.ag/430jwC9
“I’ve got 4 Red Bulls and a dream.” - one student’s proclamation on arriving to take his Organic 1 final.
At a department faculty meeting, discussing the dramatically new budget model that is being imposed on us by upper administration and by our college. The model is obviously dramatic and disastrous. Our university and college are trying to kill us.
Please join me in welcoming Dr. Megh Raj Bhatt to @MontclareLabs! Megh received his Ph.D. in Biochemistry from @ZondloLab at @UDelaware. He will be conducting research on protein engineered materials fortherapeutic applications. #postdoclife #lablife
Student during office hours: “What year did you start teaching here?” me: “2001” Student: “That’s so cool! My Mom’s friend said he took organic chemistry from you in 2003! He said he loved it!” … So that’s a new one. I am now into a second generation of students taught. #old
I am a scientist because my father taught me to try to understand the wonders of the natural world, and the rigor of the scientific method, and because he inspired me with his passionate approach to life. And so much more. R.I.P. Dad. You were the greatest.
CONGRATULATIONS to Megh Bhatt (@micromegaa) on your successful Ph.D. thesis defense! Advances in understanding the bases for stability of polyproline helix and α-helix, plus structural effects of cysteine oxidation! (Pssst: he’s looking for an industry position - hire him!)
Yep. In papers, we spend what some might consider way too much time on our Supporting Information, specifically because we want methods to be useful, and to be useful they need all of the details necessary for them to be reproducible by anyone.
A key takeaway from today’s @HeemstraLab professional development session: When writing your methods section, use the same level of detail and clarity that you would hope to find in a protocol that you need to replicate from the literature.