Yifat Merbl lab

@YMerbl

Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology

Weizmann Institue of Science

Joined August 2018

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Yifat Merbl lab@YMerbl · Mar 5

🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology 🔗 nature.com/articles/s4158… 🧵👇

YMerbl's tweet card. Nature - Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics...

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Yifat Merbl lab@YMerbl · Mar 6

Thank you for the shout-out 🙏 and for the @ERC_Research's ongoing support! @WeizmannScience

EEuropean Research Council (ERC)@ERC_Research · Mar 6

🆕 way to fight resistant superbugs? 🦠 ERC grantee @YMerbl and team @WeizmannScience revealed a secret defence in the immune system - reshaping our understanding of infection protection. 👉 bbc.in/3DnLBKL 👉 go.nature.com/3XvSX5Q @Sys_Immunology #Immunology

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Yifat Merbl lab Retweeted

ElinavLab@Elinav_Lab · Jan 20

1/14 Excited to share our new @Elinav_Lab @Elinav_DKFZ @WeizmannScience paper @CellCellPress, championed (for 6 years!) by the amazing @rvaldesmas, @AvnerLeshem, @DanpingZheng and twitter-less Alon Savidor. In this work, we’ve adopted into microbiome.. cell.com/cell/fulltext/…

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Yifat Merbl lab@YMerbl · Mar 10

Humbled and honored 🫣

SSamuel Hume@DrSamuelBHume · Mar 10

You are welcome, your paper is completely fascinating

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Samuel Hume@DrSamuelBHume · Mar 10

You are welcome, your paper is completely fascinating

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Yifat Merbl lab@YMerbl · Mar 10

Thank you for this amazing highlight of our work 🙏🙏🙏

SSamuel Hume@DrSamuelBHume · Mar 9

Top 5 advances in medicine this week (🧵) 1. An untapped treasure trove of antibiotics The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics The top hit is a peptide derived from a…

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Waggoner Lab@LabWaggoner · Mar 5

Protein waste turned into antibiotics in the proteasome as a innate defense strategy of human cells @Nature @WeizmannScience @KarinGoldberg5 @YMerbl nature.com/articles/s4158… @NatureNV by @clausen_lab nature.com/articles/d4158…

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Yifat Merbl lab@YMerbl · Mar 6

A big thank you to Tim Clausen (@clausen_lab) for writing such a thoughtful N&V about our recent paper! nature.com/articles/d4158…

YMerbl's tweet card. Nature - Proteasome cleavage changes during infection to generate antibiotics.

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Paola Antonello@Paola632898361 · Oct 1

Fascinating talk by Andrea Murachelli who defined a structure of BRCA1-A with a novel metallo-DUB Inhibitor #EMBOubiquitin24

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Paola Antonello@Paola632898361 · Oct 1

We started the last session on UPS therapeutics with a great talk by Stefan Müller @IBC2_GU on SUMO-UB network in stress mediated aggregation #EMBOubiquitin24

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Paola Antonello@Paola632898361 · Oct 1

Great talk by Wilhelm Vaysse-Zinkhöfer regarding CUL5WSB2 and how it regulates degradation in neuroblastoma #EMBOubiquitin24

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