X David Li Lab
@XDavidLiLab1
Professor in HKU Department of Chemistry，School of Biological Science and School of Biomedical Science. Epigenetics and Chemical Biology.
Tenure-Track Professoriate Position in Chemical Biology at The University of Hong Kong nature.com/naturecareers/…
Congrats to Shixian @Linlab_ZJU on this paradigm-shiftimg work. Unnatural amino acid incorporation using rare codons. Really COOL!!
🔊Check out our work in @ScienceMagazine. We identify a new weak point (TCG codon) in the codon table of mammalian cells and recode it into non-canonical amino acids (ncAAs) with impressive efficiency and selectivity. This strategy, rare codon recoding (RCR), is very different!
A new application of photo-ANA to interrogate tissue-specific protein-protein interactions is now published in PNAS. MACSPI enables tissue-selective proteomic and interactomic analyses in multicellular organisms | PNAS pnas.org/doi/10.1073/pn…
How long and how much it takes from idea to publication? Here is my tale of three molecules that I designed more than 11 years ago.
I am honored to receive this recognition from HKU, where I studied and have served for more than 12 years😊
Congrats to Prof David Li (@XDavidLiLab1) from @HKU_Chemistry and Prof Stephanie Ma (@stephaniema912) from @hkusbms on being awarded this year's #HKU Outstanding Researcher Award for their exceptional research accomplishments! 🎥youtube.com/watch?v=9g1axQ…
A Must-Read thoughtful and comprehensive review from my colleague Xuechen @LiXuechen_HKU, a Master of Chemical Protein Synthesis!!
We put a lot of thinkings and efforts in this paper. Hope this will be useful to the peptide/protein chemistry community. "Precision in Protein Chemical Modification and Total Synthesis". authors.elsevier.com/a/1i8PB8jWHEHS…
Great to visit @TheCrick institute for the first HKU-Crick symposium together with many colleagues from @hkusbms @hkumed @hku_science. As the only chemist in the symposium, I am glad to learn lots of new frontier biology.
Great to meet so many people from @hkumed @hkusbms - thanks for coming to visit @TheCrick
I am very honored to receive 2024 Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry. sciencedirect.com/journal/tetrah… Thanks to @TetrahedronChem for recognizing our works, and continuous support from @hku_science and @HKU_Chemistry
Chemical approach to deciphering tubulin 'code'. Beautiful work from @Beatfierz lab!
Our work w/ @Aumeier_Lab, @unige_en and many others @EPFL_CHEM_Tweet & @epflSV, out in @NatureChemistry, where we produce tubulins with defined PTMs and demonstrate that polyE primes MTs for detyrosination: nature.com/articles/s4155…; big congrats to 1st authors Eduard and Simon!
Time flies! Last time to the US was the summer 2019. NYC, here I am!
I would like to share with you our new work on the identification of the first bona fide 'reader' of #histone H3K79 methylation, which has been a mystery since the discovery of this modification in 2002. science.org/doi/10.1126/sc… today online in @ScienceMagazine