Wesley Wong Lab
@WesleyWongLab
We study the physical basis behind how biological systems work at the nanoscale, focusing on the role of force, using single-molecule and nanoscale methods
high-throughput single-molecule platform to study DNA supercoiling effect on protein–DNA interactions academic.oup.com/nar/article/53…
New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025.0… We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech
Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at @biorxivpreprint: doi.org/10.1101/2025.0… #Mechanobiology #SingleMolecule
Check out our latest manuscript on high-throughput force spectroscopy! We've developed a next-generation CFM with multichannel fluorescence capabilities to study the the avidity of immune-cells at the single cell level biorxiv.org/content/10.110…
High-Throughput Centrifuge Force Microscopy Reveals Dynamic Immune-Cell Avidity at the Single-Cell Level biorxiv.org/content/10.110… #biorxiv_biophys
To celebrate #DNADay, William Shih, @WesleyWongLab, & Peng Yin discuss how they're using DNA, what problems they can solve with DNA nanotechnology, and their progress towards the ambitious founding vision of our Molecular Robotics Initiative. wyss.harvard.edu/news/evolving-…
Check out our latest work on measuring cell-adhesion with the CFM on Sunday (Exhibit Hall AB at 1:45, 801-Pos/B567), and on structural single-molecule proteomics with nanoswitch calipers on Monday (204AB at 12:35, 958-FlashTalk; Exhibit Hall AB at 1:45, 1601-Pos/B554)
Just landed in Philly for @BiophysicalSoc Looking forward to Single-molecule and nanoscale subgroups tomorrow! #bps2024.
Beautiful view! Having a wonderful time at #SMBLesHouches. Thank you @RuedaLab and @NynkeDekkerLab for organizing this amazing conference.
What a view to wake up to! Looking forward to meeting everyone and hearing about all of the exciting single-molecule science at the #SMBLesHouches meeting.
It was such an enjoyable and lively dinner! Thank you @cees_dekker for flying here to speak!
One great aspect of science is its very international character where you get to meet colleagues/friends from all over the world - in this picture @WesleyWongLab @JoeLoparo @shihlab @taekjip & Sua Myoung at dinner after my seminar at Harvard.
Delighted to host @cees_dekker today for the BCMP Seminar! Packed house and lively discussions!
Please join us in-person for the BCMP seminar on Thursday, January 11 at 12:30pm by Cees Dekker, KNAW Royal Academy Professor, Dept of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology. @tudelft
Single-molecule 3D reconstruction for structural proteomics--check out our latest work just published in JACS @J_A_C_S! pubs.acs.org/doi/10.1021/ja…
Going to the @BiophysicalSoc meeting 2024 in @PhiladelphiaGov? Interested in Single Molecule Mechanisms? In Tweezing & Visualizing one molecule at a time? Then you are invited to our subgroup dinner on Sat evening, 2/10/24! Can't wait to see you all there - tickets subsidized!
Congratulations to @ardemp and the team on this beautiful work! And so proud of my former student Eric!
A new study by @ardemp and colleagues shows how the cellular environment can shape the structure of the mechanosensor #PIEZO1, revealing the basic molecular movements underlying channel activation scripps.edu/news-and-event… @Nature
Congrats to Colin with a special thanks to Emily and Khal!
Now online! Structural basis for membrane-proximal proteolysis of substrates by ADAM10 dlvr.it/SstpJ6
Just saw the program for #BPS2024 -- Great job @IbrahimCisse_ and @TheVillaLab !! Looking forward to it! @BiophysicalSoc biophysics.org/2024meeting#/
This is a very special program. I had an amazing time as a Rowland Fellow--full of scientific growth, creativity and exploration!
Applications are invited for the 2024 Rowland Fellowship - an extremely generous 5-year group leader position at the Rowland Institute at @Harvard ! I found it a life-changing experience and highly recommend this fantastic program. More information on our website! #science
We are very excited about our new project to develop a next-generation platform for drug discovery using DNA nanotechnology! And appreciate the incredible support of the @wyssinstitute and Northpond Labs @npv_vc ! #DrugDiscovery
Northpond Labs funds third Wyss Institute research project, this time to accelerate highly effective DNA nanotechnology-driven drug discovery. @npv_vc #DrugDiscovery wyss.harvard.edu/news/wyss-inst…