Victor Klein-Sousa
@VKleinSousa
PhD Fellow @cphbiosciphd @NMITaylorLab @UCPH_CPR 🇩🇰 | Structural biology 🤝 phages 🤝 protein folding | from 🇧🇷 | Physicist by training ✏️ (he/him)
Excited to see our work published in @ScienceAdvances! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here: science.org/doi/10.1126/sc…
I wonder if prophages would be considered doping in a bacterial Olympics. Fascinating paper.
1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77
What determines who a phage can infect? We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort. 👇 A thread!
Excited to present CryoBoltz ❄️⚡, a multiscale guidance approach for steering AlphaFold3/Boltz-1 to sample structures that are consistent with experimental cryo-EM density maps. 🧵1/7 arxiv.org/abs/2506.04490 Joint work with @axlevy0 @GordonWetzstein & @ZhongingAlong!
Had a fantastic time at the first Danish Viruses of Microbes meeting! Great to see all the cutting-edge phage research in the Nordics. Honored to present RBPseg + the tail fiber structural atlas. Thanks for the great questions & feedback! #DKVoM25 #Phages
Exited to share that our RBPseg paper has just come out in @ScienceAdvances. Huge cograts to first author @VKleinSousa and co-authors @AritzRoa, @CloudyKielkopf and @sofos112 #phage #cryoEM #ArtificialIntelligence @UCPH_CPR science.org/doi/10.1126/sc…
Our latest work is out: we designed dual GLP1R/GCGR agonists—cyclic peptides that activate both metabolic receptors, entirely from sequence alone. This has never been done before. 🔗 biorxiv.org/content/10.110…
How can artificial intelligence overcome the computational limitations of predicting complete bacteriophage tail fiber structures that are too large and flexible for traditional experimental methods?@ScienceAdvances @uni_copenhagen "RBPseg: Toward a complete phage tail…
Contractile injection systems are used by bacteria as tools to survive, compete and interact with their environment, check out our pre-print detailing one discovered in Salmonella. @NMITaylorLab @cryoEM_Papers @UCPH_CPR @CloudyKielkopf @freddie__martin @HangryHobbit @RebrovaEva
New pre-print - 🥳🥳🥳 biorxiv.org/content/10.110…
I'm happy to see our collaboration with @phagebioUCPH @LNdsted out on npj viruses! I had a fun time modelling T-even #phages adhesin proteins. Verifying that we can use #AF2 bias to select true binders was even cooler. Congrats to Veronika Lutz and all nature.com/articles/s4429…
Excited to announce that collaborative work between the Bostina lab (@mihnea_bostina) and PHI lab (@PeterFineran) at @otago and the Wolf lab (@HiCryoEM) at @OISTedu, has been published in Nature Communications. Congratulations all :) nature.com/articles/s4146…
💛LoVis4u - a visualisation tool for comparative genomics and sequencing coverage profiles is now published! See our paper in NAR GB: doi.org/10.1093/nargab…
Two weeks left to apply to the postdoc position with us: su.varbi.com/en/what:job/jo… Are you passionate about AIxLab intersection? Come join us in beautiful Stockholm and change the world of drug design!
🚀 Calling all early-stage researchers! Need support to attend the First Symposium of the Danish Viruses of Microbes Network in Copenhagen? ✨ Travel grant applications are OPEN! ✨ But hurry—the deadline is next Friday, February 28th! 🔗 Apply here: eventsignup.ku.dk/danishviruseso…