The MOG Project

April is #MOGAD (Myelin Oligodendrocyte Glycoprotein Antibody disease) Awareness month! Take a minute to review the symptoms below. Early diagnosis is critical to proper care and disease management! #MOGADAwarenessMonth #KnowledgeIsYourSuperpower #LearnAboutMOGAD

Happy to share Syc-Mazurek et al study of attack & remission MRI in #MOGAD vs #MS ➡️ Resolution of 1 lesion predicts #MOGAD and disappearance of ≥2 lesions separates #MOGAD completely from #MS ➡️ MRI 1 yr post #MOGAD brain/spine attack may aid diagnosis👇jnnp.bmj.com/content/early/…

Guess who we’ve poached for our Medical Advisory Board? 2 outstanding Drs & researchers. Congratulations to Dr @EthelScl & Dr Benjamin Greenberg. Both of these Drs have been pivotal in helping people around the globe understand #MOGAD & we are so grateful to have them in our…

This week’s #SPIN-#POV: Have you ever spotted “dark white matter” on FLAIR images in a patient with seizures? That subtle FLAIR hypointensity can help identify the seizure focus. It’s not pathognomonic and can be seen in a variety of conditions (this was MOGAD).

🔱Do you know in which conditions the trident sign appears on spinal MRI? 🙃And what if I told you this patient showed a reversed trident sign, with ventral rather than dorsal enhancement, along with subacute paraparesis and urinary retention? 👉What would you suspect?

Which age group is more likely to be diagnosed with relapsing #MOGAD?

🚨 New paper from our lab! sCD83 is reduced in NMOSD and in relapsing MOGAD- correlates with brain volume loss and relapse risk. 📈 A promising biomarker in demyelinating diseases. Read in Frontiers in Immunology: 🔗 frontiersin.org/articles/10.33… #CD83 #Neuroimmunology

In a research letter recently published in @JAMANeuro, researchers highlighted that meningitis could be a feature of myelin oligodendrocyte glycoprotein antibody–associated disease. #MOGAD @MayoClinic Read More: neurologylive.com/view/internati…

Congratulations to Dr. Tanuja Chitnis on being named Chief of the MGB Division of Neuroimmunology!

It was really nice working on this international collaborative project on 7 Tesla #Ultrahighfield #MRI characteristics in #MOGAD. Multiple veins sign (#MVS) were commoner than central vein sign (#CVS) & intracortical vs leukocortical/subpial lesions. doi.org/10.1002/acn3.7…

🎙️ Our podcast episode out now! We discuss Plasma Exchange and therapeutics in MOGAD. Huge thanks to Dr. Chen and @EoinFlanagan14 for incredible mentorship, and to our global collaborators who made this possible! 🌍 #MOGAD #AutoimmuneNeurology #Neuroimmunology #Neurology

Happy to share @albertaboseif et al multicenter study showing 4% of #MOGAD with meningitis ➡️ Frequent misdiagnosis as infection ➡️ Updates in criteria could incorporate this phenotype ➡️ Path had meningeal T & B cells, microglia & cortical myelin loss👇 jamanetwork.com/journals/jaman…

Which option best describes MOG associated optic neuritis. #MOGAD Options: 1- Blurred vision and eye pain 2- Loss of VA, color/red desaturation, eye pain, swollen disc 3- VA loss without any pain

Real-world multicentre cohort study on choices and effectiveness of immunotherapies in NMOSD and MOGAD bit.ly/42NTGmc

Incredible working with such wonderful colleagues on this important work in #NMOSD & #MOGAD! Comorbidities are frequent in AQP4-NMOSD and MOGAD and are associated with optic neuritis frequency and disability. @guthyjacksonfdn onlinelibrary.wiley.com/doi/10.1111/en…

5 weeks left to go and registration is now open! Please register to hear expert talks about MOGAD or join in person. Link: mogproject.org/events/usmps20…

Extremely important. 24% of relapsing #MOGAD pts relapsed after discontinuation of treatment after 2 years. Relapsing MOGAD pts whose treatments were discontinued after a short period of time, also experienced higher risk of relapse, compared to monophasic patients. We really…

#WorldMSDay2025: Testing for myelin oligodendrocyte glycoprotein #MOGAD antibodies: Who, what, where, when, why, and how! Review from @adrianbudhram1 @LHSCCanada @WesternU @EoinFlanagan14 @MayoClinicNeuro ▶️ journals.sagepub.com/doi/full/10.11…

This study assessed the frequency, characteristics, and outcome of late adult-onset myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) and identified differences from early adult-onset MOGAD. hubs.la/Q03ns3Wq0 #NeuroTwitter #MOGAD

We’re currently looking for Australian &/or New Zealand expert #MOGAD doctors to come to our support zoom in a few months time to meet some of our wonderful ANZ MOG+ pts & answer some Qs. This has been done with both US, UK & Europe so Australia it’s now your turn! Looking to…

Investigating colour vision and its structural correlates 15 years following a first demyelinating event jnnp.bmj.com/content/early/…