Tomás Schmauck-Medina
@TSchmauck
🇨🇱 Scientist researching autophagy, caloric restriction and the evolutionary and mechanistic theories of aging. Nerding on the history of science and medicine
A brief summary on the Weismann's work on aging and wear-and-tear theory.
It appears that reading historical documents from the field finally pays off. If I'm not mistaken, you're referring to August Weismann's mentions of 'wear-and-tear' that are discussed in English in his 1889 publication, 'Essays Upon Heredity and Kindred Biological Problems' (1/6)
Another banger from the Cohen Lab 🔥
Inflammation isn't always bad. In our amazing new study in @NatureAging, we show that inflammaging does not exist in the typical way in two indigenous populations. It doesn't increase with age and doesn't predict chronic disease at all. #Inflammation rdcu.be/et9n6
Something to read this weekend
1/8 Why does eating less extend lifespan? 🧬 We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵 and preprint below: 🔗 tinyurl.com/jn5ryhxv
Heroic work by Ivimey-Cook, @zahidasultanova and @AlexeiMaklakov on gathering an enormous set of data. It's very cool to see how robust the effects of rapamycin and dietary restriction are across both sexes when viewed in the aggregate.
In our new paper, we show that taking the drug rapamycin delivers a lifespan extension benefit very similar to eating less across vertebrates. onlinelibrary.wiley.com/doi/10.1111/ac…
This paper couldn’t be more timely if it tried. Top-tier work from John, as always.
Calorie restriction is the gold standard for life extension. But it is not without its downsides. In this new review we detail what those are and how they arise. Congrats to co-author Yongqi Wang nature.com/articles/s4157…
Tell your friends that work on complexity science, statistical physics, biological physics or any branch of physics that they should get involved into figuring out aging.
Looking for a cool way to end 2024? How about submit your abstract to be part of the pioneering community of #gerophysics ? All biologists, physicists, and other scientists working on #aging research are welcome! #GCGP1st #conference
The first strong evidence showing that CR can significantly increase maximum lifespan in rodents (1935). This is a modified version of the classical tab, designed for easier readability. Whether or not you work on dietary restriction, what stands out to you in these results?
Next week the @NoAge100 is organizing a meeting on the challenges and responses to the issues experienced in China and the Nordic countries due to aging. noage100.com/2024/11/18/gra…
28th and 29th of November @NoAge100 is organizing with other institutions a conference on the challenges and responses to aging in China & Nordic countries.
We have PhD position advertised in evolution of ageing with Tracey Chapman and @SimoneImmler: Please contact me if you have questions about the project or about this PhD programme aries-dtp.ac.uk/studentships/m…
NO-Age member Evandro Fang (UiO/Ahus) speaks in the 73rd BSRA meeting in University of Birmingham, UK. Other speakers include Profs. Linda Partridge, Cynthia Kenyon, and Joao Pedro Magalhaes Thank you Prof David Weinkove (Chair) and youth team in making this a great one!
We visited Poland for our lab retreat with @TheFangGroupUiO. These photos are from the "Professors' Garden" at the @JagiellonskiUni, one of the world's oldest universities (est. 1364), where professors once grew and harvested fruits and vegetables for their meals.
Great paper Adrian and @CollinEwald, as usual both of your works are always interesting to see!
It’s never too late: Our new paper explores how auxin-mediated DAF-2 degradation still massively extends lifespan even at a very old age. A short 🧵 #Aging #GeroScience #AgingResearch link.springer.com/article/10.100…