Alexei Maklakov
@AlexeiMaklakov
Biology of Ageing and Life History Evolution
1/8 Why does eating less extend lifespan? 🧬 We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵 and preprint below: 🔗 tinyurl.com/jn5ryhxv
Short experimental heatwaves have sublethal impacts on male reproduction in a model insect journals.biologists.com/jeb/article/do…
Psilocybin treatment extends cellular lifespan and improves survival of aged mice 👉 “We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged…
Challenging a longevity dogma in muscle aging. Validated epigenetic clocks (pan-mammalian and muscle-specific) reveal a surprise: an 85% drop in NAD⁺ in mouse muscle leaves epigenetic age unchanged. Muscle structure, function, and mitochondria stay strong: NAD⁺ loss ≠ muscle…
Disappointing results continue to accumulate in longevity research regarding efforts to remove or replace aged blood plasma in humans. The removal of old plasma (via plasmapheresis) was thought to eliminate pro-aging factors. In Borsky et al. (2025), healthy middle aged adults…
Like an oil change for your blood: therapeutic plasma exchange (TPE) replaces old plasma with healthy fluid. Epigenetic clock analysis of a randomized controlled trial (N=42, adults 50+) found biweekly TPE with intravenous immunoglobulin (IVIG) most effective. Surprisingly, by…
Can senolytics slow aging? Recent clinical trials and the largest mouse study of senolytics to date have failed to support this notion, raising questions regarding the future of senolytics as an anti-aging therapy. The latest @NatureBiotech 🚨 1/3 nature.com/articles/s4158…
German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway link.springer.com/article/10.100…
1/7 Out now @NatureAging🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience, rejuvenation & senescence in C.elegans in response to nutrient cues, with conservation across taxa. @TJNonninger, J.Mak &B.Gerisch nature.com/articles/s4358…
Nematode mind: exploring the role of the RNA interference pathway in learning, memory and beyond | Philosophical Transactions of the Royal Society B: Biological Sciences royalsocietypublishing.org/doi/10.1098/rs…
Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity - Martini - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/ac…
Studying cancer across species can reveal new ways to understand and potentially treat cancer. Together with leading experts, we now explain why this field matters more than ever. Full text👉 rdcu.be/etKdN @ImmunoConcept @WicaneResearch @MathieuGiraude3 @ATJCagan
Exciting update! We will provide #TravelGrants to support selected early-career researchers presenting their work (talks or posters) at #AMC2025! 📌 Jena, Germany 📆 October 28-29, 2025 🔗 amc25.leibniz-fli.de
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science science.org/doi/10.1126/sc…