ScaddenLab

🎉New article from the @ScaddenLab in @Cell_Metabolism: Disrupting ELMSAN1–nPDC reactivates nuclear acetyl-CoA, rewires cancer epigenetics, and halts tumor growth. A promising strategy for cancer therapy. Read more: doi.org/10.1016/j.cmet… #MGB #HSCRB

David Scadden has been named to Clarivate’s 2021 global list of Highly Cited Researchers. His papers rank in the top 1% of citations for his field in the Web of Science database, demonstrating the impressive reach of his influential work.

A huge team effort under the umbrella of the Boston bone metastases consortium. Targeting CCL20:CCR6 axes relieves immunosuppression in bone met prostate cancer. @ScaddenLab @KharchenkoLab @SykesLabMGH @MGH_RI @Cancer_Cell authors.elsevier.com/c/1dw7q5TA51Vy…

Paul Frenette was a cherished colleague and friend whose creativity changed forever how we think about hematopoiesis and the bone marrow niche. His greatness in science was matched by his warmth, kindness and humor. We deeply mourn his loss and celebrate his life. @PaulFrenette

Our new discovery linking metabolism to mitochondrial biogenesis through ME2 enzyme, in healthy and leukemia cells is now out on @Cell_Metabolism. Congratulations to @YPWang4 and the team! @harvardstemcell @HSCRB sciencedirect.com/science/articl…

Very excited to share our work on fluorescent signaling sensors revealing unexpected mTORC1 single-cell dynamics in leukemia progression and relapse in vivo. Congrats to first author Toshihiko Oki and all authors. @MassGeneralCRM @HSCRB @harvardstemcell go.nature.com/39s5U6S

Congratulations to Nick van Gastel who is en route to his own new lab in the deDuval Institute, Brussels, Belgium.

Delighted to be part of a superb study by Aaron Burberry and Kevin Eggan defining how common ALS variant C9orf72 affects immune response to gut microbes. Microbiome speaks to the brain through blood cells and alters neurodegeneration! Nature 2020 Jun;582(7810):89-94.

Very exciting work from @EgganLab! Happy to have contributed a small bit to this study. Congrats first author Aaron Burberry and all co-authors! @HSCRB @harvardstemcell @ScaddenLab @mfwells5

Very happy to have contributed to this study, although most praise should go to @GeertLab and first author @nickvangastel (now a postdoc in @ScaddenLab) for this wonderful and exciting work!

Scientists in the @ScaddenLab at @harvardstemcell have discovered that the presence of fatty acids in blood at a fracture site drives conversion of #SkeletalProgenitorCells to bone-forming cells, while the absence generates cartilage cells. bit.ly/2T8oqdz

NEW Perspective by S Méndez-Ferrer et al outlines how the #BoneMarrowNiche contributes to the initiation & the progression of haematological malignancies & suggests guidelines to help overcome existing research challenges. bit.ly/-SMF- @NatResCancer @SCICambridge

Thanks for highlighting our study performed by @nickvangastel with help of @SteveStegen, two amazing young scientists @GeertLab and @ScaddenLab

Very exciting indeed! This paper has been long in the making and a big thank you to all co-authors @SteveStegen @ACarlier_PhD @VeerleDaniels @Baryawnolab @maarteniFixit @azeem_sharda @triziagos @LambrechtsDlab @SwinnenJohan @LiesbetGeris @bernthie @CarmelietLab @ScaddenLab 1/6

Many thanks to all our expert collaborators @ScaddenLab @CarmelietLab @bernthie @ACarlier_PhD @baryawno @triziagos @LambrechtsDlab @SwinnenJohan @LiesbetGeris and non-twitters

Very pleased and happy to share our latest publication @Nature showing that lipid starvation during #bone #regeneration promotes chondrogenic fate of skeletal progenitors. Impressive work of @nickvangastel and our team @KU_Leuven @FWOVlaanderen doi.org/10.1038/s41586…