Saumya Das

Delighted to attend and present at #RNATx2024 @RTI_UMassChan our work on tRNA derived small RNAs and their role in kidney disease, led by @GuopingLi2 with many collaborators. Some robust discussion on defining mechanisms and designing therapeutics.

Lab transitions/graduations: sad and happy at the same time. Guoping Li: congratulations on Assistant Prof position at MGB/HMS; Michail Spanos: Physician-scientist residency at Jacoby/Sinai; Olivia Whitaker/Lingfei Sun: MD/and or MPH! @mghcvrc

A lot of fun to visit Jose Huizar, Fadi Salloum @VCUHealth to talk about translation of basic discovery to human studies led by @ThryvTrx and our work on cardiac specific EVs led by @Michail_Spanos_ @PriyankaGokuln and @GuopingLi2

The study was possible with funding from @AmericanHeart and @nih_nhlbi. Work done collaboratively with @mghcvrc @TGen and @VUMChealth. First study to show mapping of EV transcripts to single nuclear RNAseq atlas. ahajournals.org/eprint/KAIQX6T…

How can one non-invasively sample the transcriptome of organs like the heart. Our study now published in @CircAHA shows the mapping of differentially expressed transcripts in HFpEF and HFrEF mapping to different cardiac cell-types. ahajournals.org/eprint/KAIQX6T…

4 years of hard work led by Dr. Guoping Li to develop tools to manipulate tDR expression and careful studies to understand the mechanistic link between tDR and cellular response to injury. Now poised as possible new therapeutics! @GuopingLi2 @mghcvrc

Our work on the discovery of cardiac specific EVs and analysis of their cargo RNAs as representative of cardiomyocyte disease pathways was well received at the GRC-EV conference. #GRCconference, @mghcvrc

So cool to have amazing summer students and interns from across the world and the US work with us to get a good sense of research in the clinical/translational arena. Meaningful contributions to several projects. @mghcvrc

RNA therapeutics and gene/RNA editing will allow for truly personalized approaches to therapy. Important for patient voices and what matters for outcomes to be heard by regulators and scientists alike.

Lab members and families out for summer celebration of transitions, successes (papers, talks). Lots to celebrate.

tRNA-derived small RNAs have burst in the scene as novel mediators of cellular stress responses. Was a pleasure to present some of our work on Asp-GTC-3'-tDR playing a role in RNA autophagy in kidney cells at the RNA therapeutics conference @cityofhope

Our new study in collaboration with Abbott showcases the potential of adding plasma miRNA biomarkers to traditional protein biomarkers. Effect sizes still small, but point to interesting pathways. doi.org/10.1002/ehf2.1…

Congratulations to Marta Garcia Contreras from our group for being selected as a Rising Star at the NIA conference on biomarkers of stress and resilience. Microglial EVs may reflect disease state in neuroinflammation! @mghcvrc @NIHAging

Pleasure to present our work. Hopefully tissue specific EVs will improve the diagnostic yield of EV biomarkers; specificity of antibodies remains a challenge down the road.

Really great forum from the historical perspective to the role of NIH-driven funding (Common Fund) to the publication landscape. @NIH_CommonFund

A big goal for AAEV is to promote trainees and provide a forum for networking. Great to see @SNEVresearch at the meeting!

Amazing turn out and fantastic talks on Day 1.

AAEV 2023 finally off the ground with a bang! Amazing talks on single vesicle imaging and tools to capture with plasmonics! @mghcvrc @AAEV_org