Samrat Mukhopadhyay
@SamratLabMohali
Professor @IISERMohali Studying protein-RNA condensates using single-molecule/super-resolution methods Editor @BiophysJ Attended @IIScBangalore @ScrippsResearch
Happy to share our latest (4th) paper in Nature Communications @NatureComms on energy migration via homoFRET to study biomolecular condensates in vitro & in situ (in cells). Congratulations to peerless @AshishJ87810510 @anuja_walimbe, et al. @IISERMohali. doi.org/10.1038/s41467…
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…
What an excellent review article by my former PhD student, Priyanka Dogra @PriyankaDogra07, with @kriwacki @StJudeResearch on "Phase separation via protein-protein and protein-RNA networks coordinates ribosome assembly in the nucleolus" published in BBA. doi.org/10.1016/j.bbag…
Happy to share our latest review article, highlighting how phase separation—driven by protein–protein and protein–RNA interactions—underpins the organization of ribosome assembly within the nucleolus. sciencedirect.com/science/articl…
We (and many!) have been thinking a lot about how to quantifiably measure the material properties of biomolecular condensates inside cells. Chris @ChrisabcdeAoM wrote this great review article about microscopy-based techniques link.springer.com/article/10.100… @UnivCamPharm
Glad to share our latest comment published in @NatChemEng! Here, we discuss the role of biomolecular condensates as regulators of enzymatic reactions. I hope you enjoy it! nature.com/articles/s4428…
Entropy-driven denaturation enables sustainable protein regeneration through rapid gel-solid transition: nature.com/articles/s4146…
Amino acid transfer free energies reveal thermodynamic driving forces in biomolecular condensate formation | PNAS pnas.org/doi/10.1073/pn…
It was wonderful to speak with @Sci_community_ yesterday. If you want to watch my interview, here's the link (duration: 1h40m; if you want, you can watch it at a 1.25x playback speed). youtube.com/live/6V1OOnctq…
We’re back with a fantastic event! 🤩 "From Fold to Fail: How Proteins Go Rogue in Molecular Mayhem" 🪢 👨🔬 Dr. Samrat Mukhopadhyay, IISER Mohali 🗓️ July 20, 2025 🕥 10:30 AM IST 🎟️ Register: shorturl.at/epH9M E-certificates for attendees! #proteins #dbt #biochem #iiser
I'm looking forward to interacting with students & postdoctoral fellows on Sunday, July 20, at 10:30 AM (Delhi/Mumbai), 2 PM (Tokyo), 6 AM (London), 1 AM (New York) & 10 PM, July 19 (San Francisco). Thanks to @Sci_community_ for organizing this event. thescicommsynapse.in/event-details/…
We’re back with a fantastic event! 🤩 "From Fold to Fail: How Proteins Go Rogue in Molecular Mayhem" 🪢 👨🔬 Dr. Samrat Mukhopadhyay, IISER Mohali 🗓️ July 20, 2025 🕥 10:30 AM IST 🎟️ Register: shorturl.at/epH9M E-certificates for attendees! #proteins #dbt #biochem #iiser
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function dlvr.it/TLzqpf
Disorder meets its match | Science science.org/doi/10.1126/sc…
We’re back with a fantastic event! 🤩 "From Fold to Fail: How Proteins Go Rogue in Molecular Mayhem" 🪢 👨🔬 Dr. Samrat Mukhopadhyay, IISER Mohali 🗓️ July 20, 2025 🕥 10:30 AM IST 🎟️ Register: shorturl.at/epH9M E-certificates for attendees! #proteins #dbt #biochem #iiser
Congrats to Jing @jesszhiyuezhao & @DNAmyStrom on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR
How short peptides disassemble tau fibrils in Alzheimer’s disease | Nature nature.com/articles/s4158…
Inspiring piece in @NatureCancer, "An unexpected career in cancer metabolism," highlights Dr. Ralph DeBerardinis & the pivotal moments that prompted him to pursue a career in cancer metabolism. @CRI_UTSW @HHMINEWS nature.com/articles/s4301…
SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in @nchembio presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/4eARnXz
Really excited to share this Perspective from John Danial covering how technology is moving the field of fluorescence microscopy toward structural biology. nature.com/articles/s4159…
Yesterday, I had a great visit/seminar/discussion at the University of Lorraine, Metz, then arrived in Paris in the evening & had a breathtaking view of Paris from Eiffel Tower. Now at Paris CDG airport & will fly to Delhi. Had a wonderful time in France. Au revoir, Paris/France!
I arrived in Metz, a beautiful city in the northeast Lorraine region of France. Had an amazing French dinner with my host, Dr. Therese Malliavin. I walked around the city center & Square du Luxembourg. Looking forward to visiting & speaking at the University of Lorraine tomorrow.
A new and simple model-free method to analyze smFRET experiments. Protein dynamics from nano- to milliseconds without the nasty diffusion decays in standard FCS experiments - kudos to the great Ivan Terterov! Have a look! nature.com/articles/s4146…