Rothstein Lab

@Rothstein_Lab

Dr. Jeffrey Rothstein is a professor of neurology and neuroscience @HopkinsMedicine and is the founding director of @packardcenter. (trainee run)

Baltimore, MD

Joined April 2023

398Following

1KFollowers

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Rothstein Lab@Rothstein_Lab · Jun 23

Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation cell.com/stem-cell-repo…

Rothstein_Lab's tweet card. In this article, Sonustun, Giacomelli, Studer, and colleagues present a 3D spinal microtissue model of C9ORF72 (C9)-ALS to study disease-related neuroinflammation. An FDA-approved drug screen...

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Rothstein Lab@Rothstein_Lab · Jun 9

Molecular Subtyping Based on Hippocampal Cryptic Exon Burden Reveals Proteome-wide Changes Associated with TDP-43 Pathology across the Spectrum of LATE and Alzheimer’s Disease biorxiv.org/content/10.110…

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Rothstein Lab@Rothstein_Lab · Jul 24

Peptidomic analysis of CSF reveals new biomarker candidates for amyotrophic lateral sclerosis embopress.org/doi/full/10.10…

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Rothstein Lab@Rothstein_Lab · Jul 24

A partial deletion of the Tardbp 3´UTR affects TDP-43 regulation and leads to motor dysfunction in mice jstage.jst.go.jp/article/expani…

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Rothstein Lab@Rothstein_Lab · Jul 24

Neurodegenerative disease in C9orf72 repeat expansion carriers: population risk and effect of UNC13A academic.oup.com/brain/advance-…

Rothstein_Lab's tweet card. The C9orf72 hexanucleotide repeat expansion is associated with ALS and certain forms of dementia, though its exact penetrance remains unclear. In a UK popu

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Rothstein Lab@Rothstein_Lab · Jul 22

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism biorxiv.org/content/10.110…

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Rothstein Lab@Rothstein_Lab · Jul 20

Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases nature.com/articles/s4159…

Rothstein_Lab's tweet card. Nature Medicine - Large-scale plasma proteomics of 10,527 samples from the Global Neurodegeneration Proteomics Consortium identified shared and disease-specific pathways in Alzheimer’s...

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Rothstein Lab@Rothstein_Lab · Jul 20

Long-read RNA sequencing unveils a novel cryptic exon in MNAT1 along with its full-length transcript structure in TDP-43 proteinopathy nature.com/articles/s4200…

Rothstein_Lab's tweet card. Communications Biology - TDP-43 dysfunction leads to aberrant splicing. We developed IsoRefiner to identify full-length transcripts via long-read RNA-seq and found a cryptic exon in the MNAT1 gene...

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Rothstein Lab@Rothstein_Lab · Jul 20

The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging nature.com/articles/s4159…

Rothstein_Lab's tweet card. Nature Medicine - The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic...

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Rothstein Lab@Rothstein_Lab · Jul 20

Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss biorxiv.org/content/10.110…

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Rothstein Lab@Rothstein_Lab · Jul 20

Impact of SOD1 Transcript Variants on Amyotrophic Lateral Sclerosis Severity mdpi.com/1422-0067/26/1…

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Rothstein Lab@Rothstein_Lab · Jul 14

Therapeutic Approaches for C9ORF72-Related ALS: Current Strategies and Future Horizons mdpi.com/1422-0067/26/1…

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Rothstein Lab@Rothstein_Lab · Jul 9

Small tau aggregates exhibit disease-specific molecular profiles across tauopathies biorxiv.org/content/10.110…

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Rothstein Lab Retweeted

Suleyman Can Akerman@CanAkerman · Jun 25

AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice nature.com/articles/s4146…

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Rothstein Lab@Rothstein_Lab · Jun 23

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids onlinelibrary.wiley.com/doi/10.1002/an…

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Rothstein Lab@Rothstein_Lab · Jun 15

“The DESCRIBE-ALS-FTD study: a prospective multicenter observational study of the ALS-FTD spectrum” tandfonline.com/doi/full/10.10…

Rothstein_Lab's tweet card. Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) exhibit significant clinical, genetic and neuropathological abnormalities, and are regarded as belonging to a commo...

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Rothstein Lab@Rothstein_Lab · Jun 15

Cell cycle dysregulation contributes to neurodegeneration in human neurons and defines a druggable vulnerability in C9orf72 ALS/FTD biorxiv.org/content/10.110…

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Rothstein Lab@Rothstein_Lab · Jun 15

Burden of pathogenetic and likely pathogenetic variants in SPG7, SPG11 and AP4 genes in Amyotrophic Lateral Sclerosis. A case-control study link.springer.com/article/10.100…

Rothstein_Lab's tweet card. Journal of Neurology - There is evidence that some Hereditary Spastic Paraplegia (HSP) genes are linked to Amyotrophic Lateral Sclerosis (ALS). In particular, KIF5A and SPG11 genes, which cause two...

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Rothstein Lab@Rothstein_Lab · Jun 15

Stress exposure affects amyotrophic lateral sclerosis pathogenesis via PI3K/Akt and focal adhesion pathways: evidence from three experimental models nature.com/articles/s4159…

Rothstein_Lab's tweet card. Scientific Reports - Stress exposure affects amyotrophic lateral sclerosis pathogenesis via PI3K/Akt and focal adhesion pathways: evidence from three experimental models

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Rothstein Lab@Rothstein_Lab · Jun 15

Safety Extension Study of Edaravone Oral Suspension in Patients With Amyotrophic Lateral Sclerosis for up to an Additional 96 Weeks of Treatment onlinelibrary.wiley.com/doi/10.1002/mu…

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