Suleyman Can Akerman

Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease nature.com/articles/s4146…

AI Decodes Hidden Features of γ-Secretase Substrates, Finds 160 New Ones alzforum.org/news/research-…

P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles researchsquare.com/article/rs-677…

Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer’s disease …arneurodegeneration.biomedcentral.com/articles/10.11…

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy nature.com/articles/s4159…

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP-43-Associated ALS and AD advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding biorxiv.org/content/10.110…

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau biorxiv.org/content/10.110…

Effects of wild-type and mutant TDP-43 on cognitive function and hippocampal neurons in mice sciencedirect.com/science/articl…

Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division rupress.org/jcb/article/22…

AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice nature.com/articles/s4146…

A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer’s disease thelancet.com/journals/ebiom…

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Barriers in the Nervous System: Challenges and Opportunities for Novel Biomarkers in Amyotrophic Lateral Sclerosis mdpi.com/2073-4409/14/1…

New study showing the development of pan-Expansion Microscopy by Morgan, King et al. @YaleMed to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation. hubs.ly/Q03rSGym0

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential …arneurodegeneration.biomedcentral.com/articles/10.11…

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress nature.com/articles/s4159…

Red Blood Cell-Derived Exosomes as Mediators of Age-Related Neurodegeneration liebertpub.com/doi/10.1089/re…

C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD biorxiv.org/content/10.110…

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase science.org/doi/abs/10.112…