Rajni Kumari
@RajniKuJ
#Singlecell #Leukemia #Singlemolecule #RNA biology Researcher, Postdoctoral Fellow in SteidlLab @Einsteinmed @Einstein_SCI. LLS CDP Fellow.
#justacrazysciencethought We are born with a homogeneous mixture of fate biased HSCs, which evolve as we encounter life events.
Cool technology! Especially for cancer and stem cell biology where every gene functions in a dosage dependent manner.
Loss of gene expression can compromise cellular fitness. In the case of such haploinsufficiency, replacement of the gene supplementation could rescue cell health. But what if you need a very precise dosage? Try ComMAND! 🧵 (1/n) Link: doi.org/10.1101/2024.0…
Sex differences alter primitive progenitors in the C57BL/6 Tet2 knockout mouse model - Experimental Hematology Thank you Sheela Abraham for this study. I had always wondered about it and kept my experiments limited to either males or even mix. exphem.org/article/S0301-…
Congratulations to my mentor @SteidlUli for inspiring Marshall S. Horwitz Faculty prize 💐
1/8 Just launched: DeepMolecules – a webserver for predicting protein-small molecule interactions using AI, now out in Nucleic Acids Research! academic.oup.com/nar/advance-ar… DeepMolecules.org @HHU_de
Are you looking for a Bangla or Hindustani classical music teacher for your kids or yourself? Please contact Anamika Bhattacharyya or me for in-person or zoom classes options: Early birds can avail decent discount too: teacheron.com/tutor/bomX #hindustaniclassicalmusic
Today's work-in-progress seminar featured Dr. Rama Kadamb from the Aguirre-Ghiso Lab and Dr. Rajni Kumari from the @SteidlUli lab with discussant Dr. @KentaNishitani from the @WenjunGuoLab.
😂😂😂
It can be hard to say no to service requests in academia. We sought advice on how to ensure researchers don’t get stuck doing unpaid labour go.nature.com/4bUX6WN
Many many congratulations to my PI Uli Steidl 😃
ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on simplyblood.org
Grateful to have our work presented at @ASH_hematology #ASH24 highlighted by @CD_AACR, showcasing the increased risk of pre-leukemic clonal hematopoiesis in 9/11-exposed first responders @MontefioreNYC @EinsteinMed aacrjournals.org/cdnews/news/19…
Very fun and productive collaboration with Bobby Bowman & @rosslevinemd modeling mutation order and oncogenic dependency in AML. I've always wanted to do this but we were previously limited by available tools... this is a huge step forward! authors.elsevier.com/c/1k4rd5TA51hP…
📖 New review in Nature Reviews Cancer on how epigenomic heterogeneity drives tumour evolution! We dive into: Check it out if you're into epigenetics, single-cell tech, or the future of cancer therapy! 📖 nature.com/articles/s4156…
What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬 biorxiv.org/content/10.110…
😍
ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on simplyblood.org
Woohoo!! Congratulations @SamuelJohnTayl1
Super thrilled to share our article on pharmacological PU.1 repositioning published in Nature Genetics today! Massive thanks to everyone involved! Article -> nature.com/articles/s4158… A digestible PUree of the main findings (aka Research Brief) -> nature.com/articles/s4158…
🤯🤯
Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract exhaustion and fight tumors more effectively @CellCellPress cell.com/cell/fulltext/…
Cell biologists! This is a fantastic statistics primer custom made for you. Very practical, must-read! From Pollard lab five years ago: molbiolcell.org/doi/10.1091/mb…
30 Essays to Make You Love Biology Day 8. "Can a biologist fix a radio?" by Yuri Lazebnik. Biology tends to catalog things by breaking them apart. Without quantitative insights, it is difficult to piece them back together into a holistic understanding. One of my favorites.