David Kuster
@RNADavid
RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. Phase separation, Aptamers & RNA fun @HymanLab. And birds @Birder_David.
It's MicroscopyMonday, so let's take a peek into the 🔬 This movie was taken by Shinya Inuoe, who built the polarizing microscope that allowed scientists to see mitotic spindle fibers live for the first time. Dr. Inuoe premiered his research at MBL.
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/sc…
How short peptides disassemble tau fibrils in Alzheimer’s disease: nature.com/articles/s4158…
Excited to share our preprint on 3'UTR-chaperoned IDR functions!Check it out if you work on a protein with a long IDR and a highly conserved 3'UTR in the mRNA!
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
Last call! 🗓️ Dr. Alexander von Appen hosts our June 26 webinar to reveal how the nucleus builds a mechano-protective barrier. Don't miss the opportunity!
Ballistic diffusion fronts in biomolecular condensates: nature.com/articles/s4156…
Material properties of biomolecular condensates emerge from nanoscale dynamics | PNAS pnas.org/doi/10.1073/pn…
Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments | PNAS pnas.org/doi/abs/10.107…
Are you looking for homologous sequences but alignments do not seem to work? SHARK-dive is available as a webserver 🦈: compare any sequences or search against precomputed IDR datasets: bio-shark.org @NAR_Open @csbdresden @PoLDresden MPI-CBG doi.org/10.1093/nar/gk…
I still remember the moment we initially observed the Demixing using STED @Abberior with Andy & David! @RNADavid Good old times :)
Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity biorxiv.org/content/10.110…
Online Now: The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states dlvr.it/TKxzZk
Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates: nature.com/articles/s4146…
Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. science.org/doi/10.1126/sc…
Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling biorxiv.org/content/10.110… #biorxiv_cellbio
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro | PNAS pnas.org/doi/10.1073/pn…
De novo design of peptides localizing at the interface of biomolecular condensates biorxiv.org/content/10.110…
Now online as a preprint biorxiv.org/content/10.110…. Thanks to the whole team for the productive collaboration! @MandyBoermel, @svenklumpe, @Reiya_Tan1guch1, @MartaKubanska, @WilflingFlorian