Rebecca Eccles

Thank you to all of our funded scientists and committee members for letting me pick your brains, here's the result! A showcase of what global team science can do🌍 Plus take a deepdive into our 7 new challenges with @CharlesSwanton

Thank you @CancerGrand team for disseminating our study on osteosarcoma cell.com/cell/fulltext/… Incredibly excited to present this and other stories from the lab on complex cancer genomes at such an unparalleled venue @royalsociety! Thanks Team #eDyNAmiC for the invite! 🙏🙌

A massive thank you to everyone at #CGCecDNA, especially our co-organisers @mischellab, Mariam Jamal-Hanjani and @HowardYChang, and all of our fantastic speakers! Together we’ll tackle the challenge of extrachromosomal DNA.

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Move over AlphaFold3. Boltz-2 has arrived, bringing affinity prediction for protein-small molecule interactions! Can’t wait to see what this group does next. It was a pleasure writing this piece. Thanks to @BarzilayRegina & @jeremyWohlwend, and congratulations to all involved!

Exceptional work from @rushika_perera identifies differential utilization of PCSK9 / cholesterol synthesis pathways and regulation of #ferroptosis as key determinants of pancreatic cancer metastasis. 🔥🤩 nature.com/articles/s4158…

🧠 How do tumours and the nervous system talk—and to what end? This question drives one of 7 open #CancerGrandChallenges. Our team explores it in a new @NeuroCellPress perspective. 📖 Read the full article:bit.ly/42MpdVh 📅 EOIs open until 18 June

🚨New in @Nature Mutographs identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases Read more about the findings, the open questions and the curiosities of colibactin 👇 features.cancerresearchuk.org/cancergrandcha…

In Focus: Tackling Cancer through Global Team Science brnw.ch/21wS5fm By @RLEccles, Gabriela Carreno, @LdelaRica, @gem_424, and David Scott @CancerGrand @CR_UK @theNCI #CancerGrandChallenges

We are finalizing the programme of our @CancerGrand Challenges Conference on #ecDNAs (June, London🇬🇧), and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇 cancergrandchallenges.org/ecDNA-2025

Join our very own Rita Cha at the @CancerGrand Challenges Conference on extrachromosomal DNA (ecDNA) this June in London. For more details about the conference and registration, check out: dlvr.it/TJVmQV

Read more about the 7 new #CancerGrandChallenges in this commentary published today: aacrjournals.org/cancerdiscover…

New Challenges just announced!! £20m per international team! -The dark proteome -Mechanisms driving mutational signatures -AI-human collaborations in cancer -Cancer avoidance -The nervous system and cancer -Rewiring cancer cells -TME dynamics More info: cancergrandchallenges.org/new-challenges…

Exciting news for the cancer research community! Read more about the new challenges now in @CD_AACR: doi.org/10.1158/2159-8…

🚨2 weeks left to submit your abstract on ecDNAs for the first ever ecDNA-focussed conference! Don't miss out on this historical moment!

Today in @Nature we share our back-to-back stories with @nzhenguw revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

The first paper from the #Cancer_Neuroscience Lab @TheCrick just got published in @Nature ! Checkout how lung cancer cells form their own electrical network and use that to promote malignancy, and how #intratumoural_heterogeneity and #lactate_shuttle play a role in that👉

Join us @royalsociety in June for the first conference focused on all things extrachromosomal DNA! In addition to this incredible line-up we have plenty of spots for selected talks too, submit your abstract now!

Our focus issue features reviews and research articles that explore emerging ideas about patterns in molecular biology, highlighting connections across key molecular mechanisms and their collective contribution to the function of the cell. cell.com/molecular-cell….

Super grateful and happy to be part of MATCHMAKERS and CGC!