Pat Adams

@PathologyPat

Regional Oncology Specialist @ Exact Sciences Minimal Residual Disease Monitoring

Hartford, CT

Joined September 2018

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Pat Adams@PathologyPat · Jul 24

Excited to see this masterpiece out @Nature today. In this study, @JannaHeide, @AndrasPiffko, @ErnstLengyel & colleagues @OvCa_UChicago unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.

EErnst Lengyel@ErnstLengyel · Jul 23

Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicago nature.com/articles/s4158…

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Pat Adams@PathologyPat · Jul 22

Developing serum proteomics based prediction models of disease progression in ADPKD | Nature Communications nature.com/articles/s4146…

PathologyPat's tweet card. Nature Communications - Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation and loss of kidney function, yet prognostic biomarkers remain limited....

Pat Adams Retweeted

The Journal of Immaterial Science@JImmatSci · 22 h

We turned medicinal chemistry into a card game, which takes 3-10 years to play. PDF: jabde.com/wp-content/upl…

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Mark Cuban@mcuban · 6 h

Disintermediating PBM middlemen would save Americans $100b a year says USC research. They nailed it academic.oup.com/healthaffairss…

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Stephanie Dudzinski MD, PhD@StephDudzinski · 13 h

If you have a proton center at your institution…..🙏🏻consider enrolling patients on these proton trials to help us learn more for our ☢️ #radonc patients! @NRGonc

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Pat Adams@PathologyPat · 16 h

Distinct Mitochondrial DNA Deletion Profiles in Pediatric B- and T-ALL During Diagnosis, Remission, and Relapse mdpi.com/1422-0067/26/1…

Pat Adams@PathologyPat · 16 h

TAF1 is required for fetal but not adult hematopoiesis in mice: Developmental Cell cell.com/developmental-…

PathologyPat's tweet card. Liu et al. identify distinct effects of TAF1 loss on fetal versus adult hematopoiesis using mouse models. They also show that different mechanisms control the activation of genes involved in hemato...

Pat Adams@PathologyPat · 16 h

NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling | Nature Genetics nature.com/articles/s4158…

PathologyPat's tweet card. Nature Genetics - Single-cell RNA and assay for transposase-accessible chromatin sequencing in isogenic prostate adenocarcinoma cells undergoing neuroendocrine transition identify dynamic changes...

Pat Adams Retweeted

Eric Topol@EricTopol · Jul 23

There are much more structural variants within our genomes than previously conceived, >26,000 per person nature.com/articles/s4158… nature.com/articles/s4158…

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Blood Cancer Discovery@BCD_AACR · Jul 24

ICYMI: Overcoming B-ALL Resistance to Targeted and Immune Therapies by Rational Combination Strategies brnw.ch/21wUoBP @Elvin_Wag

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The Pathologist@pathologistmag · Jul 24

Not all ovarian tumors are primary. Dr. Lauren Schwartz explains how to spot metastatic cancers hiding in plain sight — and why it matters for patient care. 👉 ow.ly/V2jI50Wg3Ce #Pathology #GynecologicPathology #OvarianCancer #Metastasis #ThePathologist

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Aaron Ring@aaronmring · Jul 23

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…

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Janira Navarro@Janiranavarro · Jul 23

Choroid Plexus Tumors -Papilloma, Ki67 <5% -Atypical papilloma, Ki67~10% -Carcinoma, Ki67~20% Dr. Ballester #USCAP25 #PathX #pathology

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Mai Elzieny@MaiElzieny · Jul 22

A Long Post About Pathology Boards I need to emphasize that this is based on my personal experience, which will most likely be totally different from others'. Here's a thread 🧵: #pathology #PathTwitter #PathX #PathBoards

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Hepatoma Research@HepatomaRes · Jul 22

Spotlight on #TAMs & Immune Cells 🔍 What’s covered: Role of TAMs in cancer progression & #immune suppression Interactions with T cells, NK cells & dendritic cells 📖 Full articl: oaepublish.com/articles/2394-…

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Blood Journals Portfolio@BloodPortfolio · Jul 21

International consensus statement on diagnosis, evaluation, and research of Richter transformation: the ERIC recommendations ow.ly/Pho750WrZxm #lymphoidneoplasia #specialreports

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Luca Licata, MD@LLicata88 · Jul 22

🚨Just out in @CCR_AACR our analysis on the recurrence timing after neoadjuvant chemo-immunotherapy in early-stage TNBC We analyzed 5 major trials 👉 Early relapse: up to 83% of all recurrences🤯 1/ 🧵 Why this matters 👇 🔗 Full article: doi.org/10.1158/1078-0…

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Annals of Oncology@Annals_Oncology · Jul 22

🆕review in press: Clinical challenges and proposed solutions for patients with invasive lobular breast cancer @ChristineDesme2 doi.org/10.1016/j.anno…

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JAMA Oncology@JAMAOnc · Jul 22

From @JAMA_current: Approximately 21 000 women are diagnosed with ovarian cancer annually in the US. This Review summarizes the diagnosis and management of high-grade serous ovarian cancer. ja.ma/44I2mv9

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Pat Adams@PathologyPat · Jul 22

Migrating immune cells globally coordinate protrusive forces | Nature Immunology nature.com/articles/s4159…

PathologyPat's tweet card. Nature Immunology - Sixt and colleagues show that, in environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and assemble a central...