Phillip Buckhaults
@P_J_Buckhaults
Scientist & Professor of Molecular Biology & Genetics. Using genomics to read the past & change the future. "Emollit Mores Nec Sinit Esse Feros"
Raindrops on roses and whiskers on kittens. Bright copper kettles and warm woolen mittens. Brown paper packages tied up with string. These are a few of my favorite things.
Nature research paper: The mutagenic forces shaping the genomes of lung cancer in never smokers go.nature.com/44g0mde
Thank you @charliekirk11 for the great conversation! This policy will save taxpayers from having to pay twice for science – once for the research and a second time for excess publishing fees. It is a win for making @NIH-funded research freely available to the public and…
BREAKING — NIH Director Jay Bhattacharya joined our show today with an EXCLUSIVE announcement that HHS has a new order capping the fees publishers can charge for making taxpayer-funded research publicly available. Science should be a tool of progress and innovation. But in…
simultaneous inhibition of UBE3A and ZER1 is very likely to cure all cervical cancers and about half of head and neck cancers by re-awakening p53 and RB from their virus-induced slumber. and as this depmap plot shows, it will be highly specific to cells containing HPV. someone…
personalized mRNA vaccines for cancer have tremendous potential to do a lot of good. the recent public negative response to mRNA vaccines is not so much against the technology, but against some of the public health policy and regulatory missteps. our public protection…
Your genome is huge. 3 billion letters. it has to be copied properly every time a cell divides. You start out as a single cell and by the time you are a 60 year old adult (or older) you have had an enormous number of cell divisions. The process of copying the DNA is pretty…
DNA methylation controls gene expression. Some genes are methylated differently depending on the tissue type. Indeed, it is this DNA methylation and the resulting gene expression that cause cells to be different in the first place. Some genes methylation change as people age.…
WATCH: @NIHDirector_Jay on @charliekirk11 discussing new #NIH policy: “We are going to limit the amount of money the NIH is willing to pay to scientific journals for having the scientific publications paid for by taxpayers available for free. There’s no good reason for…
some thoughts on human-ai relationships and how we're approaching them at openai it's a long blog post -- tl;dr we build models to serve people first. as more people feel increasingly connected to ai, we’re prioritizing research into how this impacts their emotional well-being.…
Visualize public genomics data with ease in the open online R2 platform (r2.amc.nl). the interactive highly customizable graphics makes hypothesis testing a breeze. 2700+ public data sets instantly explorable 2900+ pubmed citations to date #dataviz
this family has at least three generations of thoughtful inspired genius.
Taught my daughter’s science class about the thymus: how it looks huge at first & then “shrinks” But it’s a perspective trick because we actually grow around it Finally it really does regress but never quite vanishes Later: “Dad, the thymus is a metaphor for grief, right?”
Prostate cancer sometimes develops because of homozygous deletions in the retinoblastoma gene (RB1). when this happens, it often co-deletes a neighboring gene called NUDT15. NUDT15 is involved in breaking down a drug called Azathioprine and cells with NUDT15 deletion are more…
CRISPR gene editing of somatic cells will do a lot of good for kids born with terrible genetic defects.
Who cares if one more light goes out in the sky of a million stars? It flickers, flickers. Who cares when someone's time runs out if a moment is all we are, or quicker, quicker? Who cares if one more light goes out? Well, I do. Godspeed in the next life, Pilgrim.
With heavy hearts, my brother & I share that dad, Randy (@villagerssn), passed away yesterday around 3:30 p.m. As hard as it is to let him go, we take comfort in knowing that his body can no longer fail him—he is finally at peace. Thank you for all your thoughts and prayers.
The cardiologists at Prisma Health Heart hospital in Columbia South Carolina saved a life of an 89 year old man who was in serious heart failure and near death only 9 months ago. it's been a very dramatic demonstration of their competence AND the importance of @NIH…
Cancer is caused by mutations in genes. Mutations happen when the DNA polymerase that copies the genome during cell division makes a mistake, and inserts the wrong letter(s). Sometimes these mistakes happen as a result of chemicals or viruses or radiation damaging the DNA…