Nitzan Tal

@Nitzan_T

Joined October 2018

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Nitzan Tal@Nitzan_T · Jul 13

📢Preprint out! Excited to share my final work from the @Soreklab! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

Nitzan_T's tweet image. 📢Preprint out!
Excited to share my final work from the @Soreklab!

We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.

Found 3 new families targeting immune signaling!

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Nitzan Tal Retweeted

Sorek Lab@SorekLab · Jan 31

Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats @FrancoisRousset & @IlyaOsterman! science.org/doi/10.1126/sc…

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Sorek Lab@SorekLab · Jan 30

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats @TanaWein! Thanks Kranzusch lab! tinyurl.com/CA88DD

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Tanita Wein@TanaWein · Jan 29

Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab nature.com/articles/s4158…

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Erez Tzvi Yirmiya@ErezTzvi · Jan 23

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! cell.com/cell/fulltext/…

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Sorek Lab@SorekLab · Oct 25

We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & @IlyaOsterman

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MDMLab@MDMlab_Paris · Sep 23

In a new study, we report the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of mammalian innate immunity!! Co-led with @EnzoZ_P lab, in collab with @morehouse_ben biorxiv.org/content/10.110…

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MDMLab@MDMlab_Paris · Aug 28

Out in @cellhostmicrobe: Conservation of antiviral systems across domains of life reveals immune genes in humans. Using phylogenomics, we traced antiphage systems in eukaryotes, predicted human homologs and validated their immune function in human cells! cell.com/cell-host-micr…

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