Nathaniel Mabe,PharmD,PhD
@Nathaniel_Mabe
Assistant professor, Purdue MCMP | Interested in epigenetic plasticity in pediatric solid tumors
With 3 approved epigenetic drug classes and many more under clinical investigation, epigenetic targets are gaining traction. Here, we take survey of developments and hurdles in targeting the cancer epigenome. Thank you @NatureCancer for the opportunity nature.com/articles/s4301…
New publication by #teamneuroblastoma in the @KStegmaier_DFCI lab in collaboration with the Dent lab at MD Anderson. science.org/doi/10.1126/sc…. Happy to have helped bring this one over the finish line after the work done by @clarebear1060 and @FormanAllie.
Today marks the close of the postdoc chapter. I am fortunate to have called the @KStegmaier_DFCI home for the last 5 years. It was a privilege to work alongside so many amazing and talented scientists throughout this journey. Thank you for all the good memories!
We'll be opening lab doors in May and are recruiting a research technician with a start in May or June. If you are interested in studying pediatric cancer please reach out or apply. careers.purdue.edu/job-invite/302… @Purdue_MCMP @PUCancerInst @purduepharmacy
Amazing news to hear on a football Saturday. Thank you Trent family for your support and advocacy. Very excited to help make pediatric cancer research a priority at Purdue.
Nearly 5 years after Tyler Trent’s passing from a rare bone cancer, #Purdue University is making sure the devoted Boilermaker football fan will live on through research to cure his disease. purdue.link/Tyler-Trent-Re…
@Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology careers.purdue.edu/job-invite/282…
🌟Long-awaited proof-of-concept that CAR-T can eradicate solid tumours - and in immune cold paediatric tumours. Brava, Locatelli and Precision Medicine Team at Ospedale Pediatrico Bambino Gesù! nejm.org/doi/full/10.10…
Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. rdcu.be/c7avS
Check out two new publications on Ewing sarcoma and ETV6 in @NatureCellBio from our lab and @ChrisVakoc. Excited to see them both in press! doi.org/10.1038/s41556…
Online today in @CellCellPress! Our fab collaboration with @iaincheeseman lab: image-based screen 5K+ essential genes to build a resource defining the phenotypic consequences of disrupting core cellular processes @broadinstitute @WhiteheadInst @lukebfunk cell.com/cell/fulltext/…
Holy cow! Open call for a Researcher position (MSc or PhD, no post-doc experience needed). This will person will be a part of the Pediatric Dependencies Project - a collaboration between @broadinstitute, @DFBC_PedCare and @StJudeResearch! Cool, right? talent.stjude.org/careers/jobs/1…
Our work led by @senspeaks and @sanjuktadas25, connecting tumor cell lineage to immunogenic phenotypes in neuroblastoma, is now online in @NatureCancer rdcu.be/cV7ug. These studies highlight the immunogenic potential of the mesenchymal lineage tumors.