NIH ORIP

👨‍🔬In this #ResearchHighlight: The Center for Precision Medicine Models, at @bcmhouston, is developing animal models that can be used to end the diagnostic odyssey for patients with #rarediseases. (ORIP- U54OD030165) Learn more about CPMM: orip.nih.gov/about-orip/res….

Mark your calendars 🗓️ORIP’s #Cryopreservation workshop continues: Session V: Long-Term Preservation Methods for Nonhuman Primate Models in Biomedical Research takes place on July 15, 2025, from 12pm-5pm EDT. Learn more below and register today: scgcorp.com/Cryopreservati… @NIHAging

😍A placental #GeneTherapy approach to boosting the placenta is safe in monkeys, according to a new pilot study, which may bring treatment closer to improving birthweights of human babies. Wilson et al. (ORIP-P51OD11106, S10OD023526) pubmed.ncbi.nlm.nih.gov/39499161/

🔍Scientists identify extended survival of 9- and 10- #Gene edited #Pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression. Chaban et al., J Heart Lung Transplant, 2024. @CAFNRNews (ORIP- U42OD011140) pubmed.ncbi.nlm.nih.gov/39097214/

Our new perspective article describing the human and non-human primate developmental GTEx projects is now out in @Nature! We outline the scope, vision, opportunities and challenges of these projects here: nature.com/articles/s4158…

⚙️#ORIPResourceOfTheMonth. The National Xenopus Resource, @XenopusNXR collaborates with @ExrcXenopus, supporting the Xenopus community by providing breeding, maintaining genetic stocks & distributing stocks to researchers. (ORIP- P40OD010997). Learn more: orip.nih.gov/division-compa…

🧑‍🔬Dive into this study describing the establishment and characterization of three new cell lines, derived from human ocular adnexal sebaceous carcinoma, to serve as models for #DrugDevelopment. Lee et al., Int J Mol Sci., 2024. (ORIP-K01OD034451) pmc.ncbi.nlm.nih.gov/articles/PMC11…

Mark your calendars🐵Session V of the #cryopreservation workshop will take place on Feb. 7 from 12:00 p.m.–5:00 p.m. EST. This workshop will discuss long-term preservation methods for nonhuman primate models in #BiomedicalResearch. 👉Register today: scgcorp.com/Cryopreservati…

👉READ: “Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy.” Wang et al., PNAS, 2024. @NIH_NINDS @ColumbiaMed (ORIP support through U54OD030187, U54OD020351, S10OD026974) pubmed.ncbi.nlm.nih.gov/39374387/

Findings reveal short-term exposure to proinflammatory cytokines leads to diminished tight junction in canine intestinal organoids. Nakazawa et al., In Vitro Cell Dev Biol Anim., 2024. @WSUvetmed (ORIP- K01OD030515, R21OD031903) 👉 Learn more: pmc.ncbi.nlm.nih.gov/articles/PMC11…

✅READ: “A Comparative Review of Cytokines and Cytokine Targeting in Sepsis: From Humans to Horses.” Hobbs et al., Cells, 2024. @NCStateVetMed (ORIP support through T32OD011130) pmc.ncbi.nlm.nih.gov/articles/PMC11…

👀Researchers successfully reduced viremia in a highly pathogenic model of HIV in rhesus macaques, providing proof of concept for a new class of single-administration antiviral therapies. Pitchai et al., @theNCI (ORIP- P51OD011092, U42OD010426) pubmed.ncbi.nlm.nih.gov/39116226/

🧐READ: “Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion.” Phan et al., @NIAIDnews, @LosAlamosNatLab, @PSUScience (ORIP support through R01OD011095) pubmed.ncbi.nlm.nih.gov/38746144/

🐷READ: “Impaired skeletal development by disruption of Presenilin-1 in pigs and generation of novel pig models for Alzheimer’s disease.” Uh et al., J. Alzheimers Dis., 2024. @cafnr (ORIP support through U42OD011140) pmc.ncbi.nlm.nih.gov/articles/PMC11…