Michael Angelo
@MikeAngeloLab
Pathology and computational biology through engineering and applied physics
Registration for the 3rd Annual Spatial Biology Summit is now open! Don't miss out! Hope to see you in September.
Also! In collaboration with @parkerici, we have created a web portal to make all this data as accessible as possible. You can run your own queries or download the dataset in its entirety: bruce.parkerici.org
🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have…
Preprint of our multicenter study of human gliomas is out! Big thank you to @parkerici @CancerResearch @ACGTFoundation for supporting this work.
🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have…
Great new Stanford PI doing cutting edge spatial biology! Congrats Guolan on your new lab!
Please RT. I am currently hiring graduate students and postdoc fellows. Details can be found here: postdocs.stanford.edu/prospective/op… My lab is dedicated to developing and integrating imaging, AI, and spatial omics technologies to uncover mechanisms driving disease initiation, progression,…
I love this paper.
What limits a cell's size? One factor (and I'll explore others in an upcoming essay) is its surface area-to-volume ratio. A semi-spherical cell's internal volume grows proportionally to the cube of its radius, and its surface area grows proportionally to the square of that…
Wonder how many of my scientist friends still on here manage to ignore my alien posts. Read the article! We are supposed to be curious! variety.com/2025/tv/news/a…
“None of the government leadership I spoke to — who have access to very sensitive classified information — were debating whether this is real. None of them.” Just sayin’ hollywoodreporter.com/movies/movie-n…
You just spoke to my soul! If @DOGE actually wants to improve the NIH they should listen to this
RE: reforming NIH funding, my view is -- keep total $ the same or increase it, but: a) Do fast review (<1 month) based on 2 page applications & email exchanges for clarifying questions b) Give $ directly to investigators with broad discretion aside from "don't pocket it"
Wow.
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above…
Check out another great one from @NoahGreenwald where we look at spatial predictors of response to anti-PD1 in TNBC!
I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…
I take it @sama has never done a western blot before. Bottleneck isn't new ideas its testing them.
sam altman: “we will see diseases get cured at an unprecedented rate … what this will do to cure the diseases at a rapid rapid rate” immortality is not too far ahead. we live in the most incredible of times
Critical mass of high ranking people in USGOVT are all saying the same thing: UFOs are real and we've been studying them in secret for decades. The scientific community needs to engage and get up to speed youtu.be/DkU7ZqbADRs
More ex-military coming forward saying govt is hiding long running UFO research program newsnationnow.com/space/ufo/uap-…
Jolene has done amazing work here. QUICHE is a dramatic improvement over cell neighborhood algos we've used in the past, gets immediately to a common question we ask often: how does spatial structure between two patient groups differ?
Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…
I am deeply honored to be named by the Stanford Medicine Alumni Association this year for the “Arthur Kornberg and Paul Berg Lifetime Achievement Award in Biomedical Sciences.” As a Stanford graduate student in the 1980s, I took a remarkable class in plasmid and phage…
NPR: Second congressional hearing where former US military and intelligence officials give sworn testimony that the govt has been running a secret UFO crash retrevial program for decades npr.org/2024/11/13/nx-…
It’s finally here!! See everyone tomorrow!
We are only TWO WEEKS away from the start of the Spatial Biology Summit! It's not too late to register! We are still accepting poster abstracts until the end of this week. More info here: angelolab.com/spatial-biolog… @MikeAngeloLab @Bendall_Lab
Congratulations to Sean Bendall @Bendall_Lab who is the new co-director of the Stanford Immunology Program!
27 days until the spatial summit! We’ve opened up a new block of spots if you weren’t able to register before. Get them while they last!
SCI member @MikeAngeloLab discusses how the emerging field of #SpatialBiology will help scientists gain an in-depth understanding of the #TumorMicroenvironment and better predict patient outcomes. stan.md/4cQTB3f
What?? @GarryPNolan!! Count me in!! Spots are filling up faster than expected, please be sure to register soon if you want to join us!
Despite a minor scheduling hiccup...the Science Grandfather himself @GarryPNolan is also confirmed to be speaking! You don't want to miss this!