MeitingerOhtaLab
@MeitingerOhta
Our labs are interested in Cell Division, Centrosomes, and Cancer. We are located at the Okinawa Institute of Science and Technology.
Interested in Base Editing and Genetic Screening? Check out our method chapter: link.springer.com/protocol/10.10… Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @Addgene Many thanks to @OISTedu for supporting open access!
Check out our review on "PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential". Everything you need to know about centriole duplication, mitotic stopwatch and TRIM37-mediated cancer-specific vulnerabilities. @Midori_RuruOta onlinelibrary.wiley.com/doi/10.1002/cm…
A prolonged mitosis is characteristic of defects that drive genome instability. What are the underlying causes and broader implications of prolonged mitosis? Check out our review... authors.elsevier.com/sd/article/S09…
We are happy to share our review on the 53BP1-mediated activation of the tumor suppressor p53. We summarize the cell cycle-depend functions of 53BP1 during mitosis and interphase and address its role in maintaining a healthy tissue. authors.elsevier.com/sd/article/S09…
🔬Groundbreaking research by OIST Cell Proliferation and Gene Editing Unit and collaborators show how cells become ultimate protectors against cancer!🧬Did you know cells sense defects by measuring the duration of #mitosis? @MeitingerOhta @oegemadesai_lab ow.ly/Gknt50R4KZk
Published today in @ScienceMagazine: @UCSanDiego biologists have uncovered a quality control timing mechanism tied to cell division. The “stopwatch” function keeps track of mitosis and protects against the formation of cancerous cells. @UCSDMedSchool today.ucsd.edu/story/cell-div…
Plasma membrane damage is a new trigger of cellular senescence: Trends in Cell Biology cell.com/trends/cell-bi… Our paper is spotlighted on Trends in Cell Biol. Thank you authors!!
分からない病気は、治すことができません。 @MeitingerOhta’s Unitでは、細胞分裂はどのように正しく行われるのか、うまくいかなかった場合は何が起こるのかを研究。#がん の新たな治療 標的を探しています。#NewFacultyOfOIST @Meitinger @Midori_RuruOta 記事はこちらから⬇️ ow.ly/8MgP50QBwFW
Because you can’t fix what you don’t understand, @MeitingerOhta's unit studies how dividing cells stay healthy, what happens if those mechanisms fail and searches for new treatment targets to combat #cancer. #NewFacultyOfOIST @Meitinger @Midori_RuruOta ⬇️ oist.jp/news-center/ne…
Photo exhibition “Fascination of Science” at OIST Tunnel Gallery is open until Feb. 29!🎉These series of portraits show Nobel laureates and leading scientists from around the world by renowned German photographer Herlinde Koelbl. ow.ly/evqw50Qy9g9 @DWIH_Tokyo @DAADTokyo
Don't miss the Dynamic Kinetochore - EMBO workshop. 17 – 20 June 2024 | Caux, Switzerland Hope to see you there!
A new year and everybody is back in the lab. @Midori_RuruOta @Meitinger
Happy to share the first pre-print from the lab focusing on a closed conformation of the mammalian gamma-tubulin ring complex! biorxiv.org/content/10.110…
Many thanks to Midori Ota and Yasutaka Kakui for organizing an excellent and interactive cell division symposium at MBSJ @Midori_RuruOta @YukiHaraECBLab #MBSJ2023