Mehandru Lab @MountSinai

New result from #theonlylabever @uoftmedicine @UofT . open access link here (until Feb 2025) sciencedirect.com/science/articl… Many thanks to @Es_cheri_chia for the excellent editorial work. Hope you will find it interesting.

📢Thrilled to share our work on the ontogeny, reactivity, and function of #IgA subclasses in homeostasis and #IBD! Huge thanks to Andrea, all our amazing collaborators, and @JExpMed for their support throughout the extended revision process! It's time to celebrate🥳!

Tejedor Vaquero, Neuman, Mehr, Cerutti, @GMagri_Immuno @HMar_research et al. show that gut IgA1 & IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, & show unique changes in #IBS. hubs.la/Q02YM2zm0

#Eosinophils mitigate intestinal #fibrosis while promoting inflammation in a chronic DSS colitis model and co-culture model with fibroblasts by @jacobsinge8 @DeleuSara @gmatteoli1978 @SeverineVermei1 @VanuytselTim @bverstockt @TARGID_KULEUVEN nature.com/articles/s4159…

Anti-integrin αvβ6 autoantibodies are increased in PSC patients with concomitant IBD and correlate with liver disea… pubmed.ncbi.nlm.nih.gov/39490950/

A fantastic day celebrating the 40th anniversary of the discovery of the TCR. Check out this T cell speaker photo which includes co-discoverers Tak Mak and Mark Davis. Thanks @UofT, @uoftmedicine, @ImmunologyUofT, @thePMCF for your support.

Please RT 🙏!📢My lab at @UniBarcelona is seeking a highly motivated postdoc to lead an exciting new public-private collaborative project (UB, CRG, CSIC, OrikineBio) aimed at testing a potentially game-changing therapy for IBD. If interested, please contact me at [email protected].

Very honored to receive the International @Inserm Prize today at the French Embassy in DC. Great evening with @Inserm CEO Didier Samuel, Ambassador Lilli, and wonderful colleagues, celebrating France/US partnerships and our shared commitment to advancing science across borders.

New research from @MehandruLab describes the depletion of germinal center B cells and IgA+ plasma cells in the #GI tracts of people living with #HIV. @francescacossa1 Read more in Science #Immunology: bit.ly/3Yd0Uwg

Celebrating our PI @NinaBhardwaj! What an amazing week; elected to the National Academy of Medicine on Monday, then selected as Inventor of the Year (Mount Sinai Innovation Awards)…we are all so proud to be in your lab! Cheers 🥂!

Out now 🚨 in @AGA_Gastro is your latest update on selective IL-23p19 inhibition in IBD! Amongst other topics featuring discussion of pathogenesis, PD/PK, efficacy, safety, positioning, and more! Together with @JeanFredericCo1 @MehandruLab & @ryanungaro gastrojournal.org/article/S0016-…

Every year, @JeanFredericCo1 hosts the GI Division #IBD Retreat to address challenging topics in #IBD. We're proud to keep the tradition going this year at IBD Retreat 2024! Register here to join: form.jotform.com/kalish39/IBDre…

Great work from @MehandruLab & congrats on this #PosterOfDistinction at #DDW2024! @divyajha_phd walks us through the intricate role of cellular dynamics within the epithelial compartment and their impact on treatment responses of therapies used in #ulcerativecolitis management.

🙏🏼🙏🏼🙏🏼pumped for the naik lab move to @SinaiImmunol and to be part of this vibrant and exciting community of immunologists and for the breakthrough discoveries we will make together @MiriamMerad @brianbrown #naiklabmoveuptown

🍾CONGRATULATIONS🍾 to the fantastic @DrShrutiNaik on winning this year's @LeoFondet award in recognition of her visionary skin research program encompassing dermatology, neuroimmunology and more! Read all about it >>> leo-foundation.org/en/2024/05/17/…

Thank you for the highlight @ScienceMagazine! 🔦 science.org/doi/10.1126/sc… 📄science.org/doi/10.1126/sc…

How does vedolizumab work in ulcerative colitis patients? Researchers in a new @SciImmunology study say the drug targets gut-associated lymphoid tissue. Learn more: scim.ag/6KJ

Explore Dr. Saurabh Mehandru's latest research uncovering vedolizumab's impact on gut-associated lymphoid tissue (#GALT) in #IBD treatment. Gain fresh insights into therapeutic response mechanisms: bit.ly/3QiGUoJ

How does vedolizumab work in ulcerative colitis patients? Researchers in a new @SciImmunology study say the drug targets gut-associated lymphoid tissue. Learn more: scim.ag/6Im

Check out our new work in @SciImmunology! Gut-associated lymphoid tissue targeting in IBD. New insights into vedolizumab MOA @IcahnMountSinai @SinaiImmunol @MountSinaiGI