Matt Burke

Excited to share my @JAMANeuro Viewpoint. Dismissive attitudes and inadequate management of patients with ‘functional’ disorders has created a silent epidemic. Very grateful to my early mentors in this field @jonstoneneuro @MarkHallett007 @valvoon jamanetwork.com/journals/jaman…

Cool study on TBI-induced remission of addition! I tried to get the lesion-tract mapping by setting lesion as ROI on the HCP1065 template and run fiber tracking. Results show TBI disrupted 1. uncinate (red) 2. IFOF (green) 3. ant thalamic rad (pink) 4. local U-fibers (blue)

1/ Just out in @NatureMedicine : we show the opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone pre‑treatment reducing acute glutamatergic activity and acute antidepressant effects. nature.com/articles/s4159…

One of my long term patients made me a survivor immunity necklace. Days like today make me love my job and appreciate the importance of building rapport in managing chronic disease. This is necklace is now my entire personality, by the way. Hey, @survivorcbs , time to get me on…

Dr. Matthew Burke (@MattBurkeMD): “Expectations, Brain-Body Circuits and Neuropsychiatry: Why Weren't We Taught a Third of Medicine” Date: Tuesday, July 15th, 2025 Time: 7:00 PM – 8:00 PM EST Platform: Zoom (pre-registration required) Registration link: tinyurl.com/Grandrounds12

Great to see! @UofT 🤝 @Harvard

We view the placebo effect as negative. In reality, it shows that our beliefs can directly shape our minds. We should instead master the placebo effect to revolutionize medicine.

Great to be part of the first-ever Functional Neurological Disorder (FND) symposium @CNSFNeuroLinks 🇨🇦🧠 While long over due, hopefully this is the first of many to come @SarahLidstone @GGilmourMD @lauren_sham @MollicaAdriano & Sarah Hanafi @uoftmedicine @UCalgary @mcgillu

🚨🍄 Major new preprint alert 🍄🚨 I think these will be important results. They are not going make me popular with my #psychedelic in-group, please do not shoot the messenger! The premise of this pre-registered meta analysis (osf.io/preprints/psya…) is that it is biased to…

🧠 New paper out in BJPsych Bulletin: We surveyed psychiatry trainees across the UK— >40% are interested in #neuropsychiatry, but only 10% expect to get enough training. Trainees want: ✔️ More access ✔️ Neurology integration ✔️ Formal accreditation doi.org/10.1192/bjb.20…

.@braincomms paper by C. Westlin. fMRI study in #FND vs psychiatric controls showing increased crosstalk btw the somatomotor network & multiple other networks (e.g., salience, default mode, frontoparietal). Correlations w physical symptoms. @FNDSociety academic.oup.com/braincomms/art…

🚨 New preprint! 🚨 Inform and Do No Harm: A Novel Approach to Reduce Negative Effects of Mental Health Awareness My student Dasha Sandra tackled growing concerns about false self-diagnosis following awareness efforts and found a promising solution. Thread /1 With @zindelsegal…

🔥Most important paper of 2025🔥 👉Injury/disease don't reliably predict pain 👉Biomarkers alone can't explain pain 👉PSYCHOSOCIAL factors reliably predict chronic pain 👉Painful conditions can be predicted from the SYNERGY btwn bio + psychosocial factors tinyurl.com/jiksh

Outstanding #BrainMedicine conference led by @drsaramitchell & #SarahLevitt from the University of Toronto! Great to see momentum growing to erode silos & integrate neurologic, psychiatric, & rehabilitative perspectives for complex brain disorders. @SarahLidstone @MattBurkeMD

Our new study in @AJGPsych shows a significant correlation between depressive symptoms and tau accumulation tracked via longitudinal PET imaging. Important implications for understanding depression in neurodegenerative conditions. Read more:

🧠 Concussion or FND—or both? Join Dr. Matt Burke, Neurologist at Sunnybrook Health Sciences Centre, as he explores the clinical overlap & how to approach diagnosis + care. 🔗 Register: bit.ly/3FsfJoS

Very honoured to receive the @AANmember 2025 Norman Geschwind Prize for my research trying to better understand complex disorders and phenomena at the interfaces of Neurology and Psychiatry Very grateful to all of my mentors and colleagues @Sunnybrook @uoftmedicine @harvardmed

Standing room only for 2 hour symposium on functional neurological disorder at the #AAN2025 meeting - with a focus on functional seizures, post concussive syndrome / functional cognitive disorder & pathophysiology. #BarbaraDworetzky @MattBurkeMD @AANmember

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @NatureComms we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s4146… A 🧵 below:

A few highlights so far from the Azrieli brain medicine group @anpadirect congrats to our successful poster presenters and young investigator award winner Adriano Mollica!! @uoftmedicine @UofTPsych @UofTNeurology @Sunnybrook @azrielifdn