Nathan Lord
@LordLab_Pitt
Asst. Professor in @compbiopitt. Our lab is interested in cell fate decisions in embryos, noisy signaling and optogenetics.
We’re very excited to share the first preprint from my lab along with @h4rrymcnamara, @BillZJia, @AdamEzraCohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development. biorxiv.org/content/10.110…
It's new-preprint-from-the-lab day! (In my opinion the most fun + authentic day to celebrate a new publication.) Check it out: "Large-scale control over collective cell migration using light-controlled epidermal growth factor receptors" biorxiv.org/content/10.110…
I wrote a 'Behind the Paper' blog post for @the_Node narrating the origin story of our recent @NatureCellBio paper on recording signals during gastruloid symmetry breaking. have a read if you're curious! thenode.biologists.com/behind-the-pap…
Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!
Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! biorxiv.org/content/10.110…
My team at Deepmind (protein design) is hiring an experimentalist with enzyme expertise. Please RT and/or apply! I'm happy to answer any questions as well. boards.greenhouse.io/deepmind/jobs/…
Get in on the ground floor! Working with @h4rrymcnamara was a highlight of my scientific career. He is brilliant, creative, and a joy to work with. His lab is going to do awesome things. Definitely seek him out if you're looking to get into developmental biology for PhD/postdoc.
a personal update: in January, I'm moving to Yale to join @MCDB_Yale and to open my lab in the @WuTsaiYale Institute! We will investigate multicellular self-organization using synbio tools to read and write developmental signals in stem cell models. syndevbio.org
Our paper “Dynamics of morphogen source formation in a growing tissue” with first authors R. Ho and K. Kishi is published in @PLOSCompBiol 🎉 We show that the floor plate of the vertebrate neural tube forms in two phases: rapid specification followed by growth. 🧵1/7
What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬 biorxiv.org/content/10.110…
Working on this paper with @h4rrymcnamara was just an absolute pleasure, one of the highlights of PI life so far. Even better: he'll be starting his own laboratory in just a few months at Yale - so stay tuned for more exciting work from the McNamara group!
Our study decoding gastruloid symmetry breaking is now live @NatureCellBio! rdcu.be/dVMLG Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):
Check out our latest preprint on FGF/ERK signaling in 2D gastruloids: biorxiv.org/content/10.110…
Thank you @BWFUND for supporting our work decoding stem cell self-organization! Thrilled to join this community of investigators at the interface of the biological and physical sciences. This award will provide a huge lift to my next phase (more news on that soon! 😺)
Announcing the 2024 Career Award at the Scientific Interface recipients buff.ly/3zyLYjp #bwfcasi
So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of @AriSarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12
Our latest: a new optogenetic system for precise spatiotemporal control of gene expression We use it to dissect the dynamics of Shh gradient formation & patterning A thread 🧵 biorxiv.org/content/10.110…
Join us for the 2024 Optogenetics Technologies conference in Boston! Outstanding lineup including: @AdamEzraCohen, @KhammashLab, @MoeglichLab @toettch @ProfJohnARogers @DunlopLab @coledeforest , Haifeng Ye + many more. 🗓️Sept. 10-12 Abstracts due 6/7! aiche.org/sbe/conference…
1/ Our work on unified principles for Topographic Deep Artificial Neural Networks is finally out in Neuron! 7 years in the making. tinyurl.com/2dtkh9fc
I am incredibly excited and honored to be running for the Secretary position for the Society of Developmental Biology! If you are a member, I would appreciate your support and your vote. I'd love the opportunity to serve our community in this way. Thanks!! Plz RT!
Congratulations to you and @elecamagu ! Wonderful story.
It is great to finally see this story on how pluripotent cells interpret signals combinatorially in making decisions out @CellSystemsCP Led by the super talented @elecamagu now starting her own group at @CABD_UPO_CSIC cell.com/cell-systems/f…
This looks amazing!
How do cells efficiently respond to stress? Transcriptional stress responses are well-known—and in our latest study, we discover that cells use biomolecular condensation to redirect translation from old to new mRNAs 1/n biorxiv.org/content/10.110…